中文名
重组蛋白IFN-beta Protein, Human, Tag Free, CHO
英文名
IFN-beta Protein, Human, Tag Free, CHO
描述
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of mostvertebratesinresponsetochallengesbyforeignagentssuchas viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for thetreatmentofrelapsing-remittingmultiplesclerosis.Therecombinant IFN beta protein has the theoretical potential to either treat or cause autoimmuneneuromuscular disorders by alteringthecomplicatedand delicate balances within the immune system networks. It is the most widelyprescribeddisease-modifyingtherapyformultiplesclerosis(MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remittingMS.IFNbetatherapywasshowntobecomparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression.Inadditiontothecommonantiviralactivity,IFNbetaalso inducesincreasedproductionofthep53geneproductwhichpromotes apoptosis,andthushastherapeuticeffectagainstcertaincancers.The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the developmentofachronicprogressiveCNSinflammation。
氨基酸序列
MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY
EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL
HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
分子量
The protein has a predicted MW of 20.02 kDa. It migrates to 20-23 kDa band in SDS-PAGE under reducing conditions due to the glycosylation.
内毒素含量
<1.0 EU per 1 µg of the protein by the LAL method.
活性
Determined by a cytotoxicity assay using human TF-1 cells. The ED50 for this effect is ＜0.3 ng/mL.
组分
Lyophilized from sterile PBS, pH 7.4, 7% trehalose.
复溶方法
Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
储存
Stored at -20 to -80°C for 12 months as supplied from date of receipt；2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid repeated freeze-thaw cycles.
关键词
Interferon beta;IFN-beta;IFNB1;IFB;IFNB
阿达玛斯 - 生命科学（Adamas-life®）自 2020 年成立以来，始终深耕高端生物试剂领域，致力于为生物医药、临床诊断、食品环境、基础科研等多行业提供全流程解决方案，是国内生命科学试剂行业的创新引领者。
我们以高标准质控体系为基石，严格遵循国际质量管理规范，确保产品品质达到行业领先水平；依托专业研发团队与国内外顶尖生物科技公司的深度合作，持续开展技术和产品创新并突破多项技术瓶颈，实现众多进口试剂的国产化替代，有效降低研发与生产制造成本。我们将坚守创新初心，深化技术突破与产业协同，加速迈向全球生物试剂领域标杆品牌，为推动生命科学产业发展注入中国力量。
