铜催化不对称 C-H 活化 手性官能化核心试剂组合
2026-10-12 · 推荐产品 · 百灵威授权转载
在现代手性合成领域,不对称 C-H 键官能化是直接构建手性 C-C、C-N、C-O 键的高效策略,无需预先官能团化,步骤经济性高,广泛应用于手性药物中间体、天然产物、功能有机分子的研发与生产。铜催化体系凭借原料廉价易得、低毒环保、底物适配范围广、反应条件温和等优势,已成为不对称 C-H 活化、炔丙基胺化、自由基偶联等反应的主流选择。
为助力客户快速搭建高效稳定的铜催化不对称反应体系,我们精心遴选多种高品质铜催化剂前体与经典手性氮配体,重磅推出铜催化不对称 C-H 活化体系核心试剂组合。套装覆盖不同价态与阴离子的铜源,搭配 PyBOX 系列、双恶唑啉等多骨架手性配体,可灵活匹配不同底物的反应活性与立体选择性需求。全系列产品纯度优异、批次稳定性强,可直接用于实验室条件筛选与工艺优化,一站式满足铜催化手性反应核心试剂需求。
铜催化剂前体
| 品名 | CAS | 货号 |
|---|---|---|
| Copper(II) acetate monohydrate, 98%, for synthesis 一水合醋酸铜 | 6046-93-1 | 358729 |
| Copper(II) trifluoromethanesulfonate, 98%, for synthesis 三氟甲烷磺酸铜(II) | 34946-82-2 | 902922 |
| Copper(I) iodide, 98%, for synthesis 碘化亚铜(I) | 7681-65-4 | 945192 |
| Copper(I) chloride, 98% 氯化亚铜(I) | 7758-89-6 | 952467 |
| Tetrakis(acetonitrile)copper(I)hexafluorophosphate, 97% 六氟磷酸四乙氰铜 | 64443-05-6 | 311161 |
手性氮配体
PyBOX 系列(吡啶双噁唑啉)
| 品名 | CAS | 货号 |
|---|---|---|
| 2,6-Bis[(4R)-(+)-isopropyl-2-oxazolin-2-yl]pyridine, 98% 2,6-双[(4R)-(+)-异丙基-2-噁唑啉-2-基]吡啶 | 131864-67-0 | 353382 |
| 2,6-Bis[(4S)-(-)-isopropyl-2-oxazolin-2-yl]pyridine, 99% 2,6-双[(4S)-(-)-异丙基-2-噁唑啉-2-基]吡啶 | 118949-61-4 | 358083 |
| 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine, 98% 2,6-双[(4R)-4-苯基-2-噁唑啉基]吡啶 | 128249-70-7 | 299174 |
| 2,6-Bis[(4R)-4-tert-butyloxazolin-2-yl]pyridine, 98%, ee: ≥99% 2,6-双[(4R)-4-叔丁基-2-噁唑啉基]吡啶 | 185346-17-2 | 255623 |
| 2,6-Bis[(4S)-4-tert-butyloxazolin-2-yl]pyridine, 98%, ee: ≥99% 2,6-双[(4S)-4-叔丁基-2-恶唑啉基]吡啶 | 118949-63-6 | 532584 |
| 2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine, 98% 2,6-二[(4S)-4-苄基-2-噁唑啉基-2-基]吡啶 | 151670-69-8 | 1711240 |
| 2,6-Bis[(4R)-4,5-dihydro-4-(1-methylethyl)-5,5-diphenyl-2-oxazolyl]-pyridine, 98% 2,6-双[(4R)-4,5-二氢-4-(1-甲基乙基)-5,5-二苯基-2-噁唑基]吡啶 | 828918-24-7 | 976449 |
| 4-Bromo-2,6-bis[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]-pyridine, 95% 4-溴-2,6-双[(4S)-4,5-二氢-4-苯基-2-噁唑基]吡啶 | 1190936-03-8 | 1710789 |
| 2,6-Bis(4,5-dihydrooxazol-2-yl)pyridine, 95% 2,6-双(4,5-二氢噁唑-2-基)吡啶 | 165125-95-1 | 2319863 |
PyOX 系列(吡啶单噁唑啉 / 异喹啉噁唑啉)
| 品名 | CAS | 货号 |
|---|---|---|
| (S)-2-(4-Isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine, 95% (S)-2-(4-异丙基-4,5-二氢-噁唑-2-基)-吡啶 | 108915-04-4 | 1682827 |
| (S)-4-tert-Butyl-2-(2-pyridyl)oxazoline (S)-4-叔丁基-2-(2-吡啶基)恶唑啉 | 117408-98-7 | B4104 |
| 2-[(4R)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine, 98% 2-[(4R)-4-叔丁基-4,5-二氢-2-恶唑基]吡啶 | 242482-28-6 | 9188718 |
| 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine, 97%, ee: 98% 2-[(4R)-4-(1,1-二甲基乙基)-4,5-二氢-2-噁唑基]-5-(三氟甲基)吡啶 | 1428537-19-2 | 1947980 |
| 1-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 97%, ee: 98% 1-[(4R)-4,5-二氢-4-异丙基-2-噁唑基]异喹啉 | 280755-83-1 | 9108698 |
| 1-[(4S)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 97%, ee: 98% 1-[(4S)-4,5-二氢-4-异丙基-2-噁唑基]异喹啉 | 1701405-00-6 | 9108699 |
双噁唑啉(BOX / SaBOX / IndaBOX)系列
| 品名 | CAS | 货号 |
|---|---|---|
| 2,2'-Isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline], 98%, for synthesis 2,2'-异亚丙基双[(4S)-4-叔丁基-2-噁唑啉] | 131833-93-7 | 972653 |
| (S,S)-2,2'-Isopropylidenebis(4-isopropyl-2-oxazoline), 97%, ee: 98% (S,S)-2,2'-异亚丙基(4-异丙基-2-恶唑啉) | 131833-92-6 | 789224 |
| (R,R)-2,2'-Isopropylidenebis(4-isopropyl-2-oxazoline), 97%, ee: 98% (R,R)-2,2'-亚异丙基双(4-异丙基-2-恶唑啉) | 150529-94-5 | 2572012 |
| (+)-2,2'-Isopropylidenebis[(4R)-4-benzyl-2-oxazoline], 98% (+)-2,2'-异亚丙基双[(4R)-4-苄基-2-噁唑啉] | 141362-77-8 | 620798 |
| (4S,4'S)-2,2'-Cyclohexylidenebis[4-tert-butyl-4,5-dihydrooxazole], 98% (4S,4'S)-2,2'-环己亚基双[4-叔丁基-4,5-二氢恶唑] | 298693-04-6 | 9108718 |
| (4S,4'S)-2,2'-(Cyclopentane-1,1-diyl)-bis(4-isopropyl-4,5-dihydrooxazole), 95% (4S,4'S)-2,2'-(环戊烷-1,1-二基)-双(4-异丙基-4,5-二氢噁唑) | 1379452-52-4 | 1561126 |
| (3aR,3'aR,8aS,8'aS)-2,2'-Cyclopentylidenebis[3a,8a-dihydro-8H-indeno[[1,2-d]oxazole], 98% (3aR,3'aR,8aS,8'aS)-2,2'-环亚戊基双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑] | 2005443-90-1 | 9075823 |
| (3aR,3'aR,8aS,8'aS)-2,2'-(1-Methylethylidene)bis[3a,8a-dihydro-8H-indeno[[1,2-d]oxazole], 98%, ee: 99% (3aR,3'aR,8aS,8'aS)-2,2'-异丙叉双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑] | 189623-45-8 | 2698458 |
| (+)-2,2'-Methylenebis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[[1,2-d]oxazole], 98% (+)-2,2'-亚甲基双[(3aR,8aS)-3a,8a-二氢-8H-茚并[[1,2-d]噁唑] | 180186-94-1 | 396000 |
| (3aS,3'aS,8aR,8'a'R)-2,2'-Cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[[1,2-d]oxazole], 98%, ee: 99% (3aS,3'aS,8aR,8'a'R)-2,2'-环丙亚基双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑] | 182122-08-3 | 9135422 |
| (3aR,3'aR,8aS,8'a'S)-2,2'-Cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[[1,2-d]oxazole], 98% (3aR,3'aR,8aS,8'a'S)-2,2'-环丙亚基双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑] | 229184-98-9 | 9135421 |
| (3aS,3'aS,8aR,8'aR)-2,2'-(1-Methylethylidene)bis[3a,8a-dihydro-8H-indeno[[1,2-d]oxazole], 98% (3aS,3'aS,8aR,8'aR)-2,2'-异丙叉双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑] | 175166-51-5 | 2698457 |
| (S)-BTBBPh-SaBOX, 99% (S)-BTBBPh-SaBOX 配体 | 1428328-51-1 | 1579645 |
| (S)-BnPh-SaBOX, 98.5% (S)-BnPh-SaBOX 配体 | 1404433-37-9 | 1579642 |
| 4,6-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan, 97% 4,6-双((S)-4-异丙基-4,5-二氢噁唑-2-基)二苯并[b,d]呋喃 | 409312-96-5 | 9189366 |
| (4R,4'R)-2,2'-(Cyclohexane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole), 97%, ee: 98% (4R,4'R)-2,2'-(环己烷-1,1-二基)双(4-苯基-4,5-二氢噁唑) | 2271404-99-8 | 9222284 |
| (4S,4'S)-2,2'-Cyclopentylidenebis[4,5-dihydro-4-phenyloxazole], 97%, ee: 98% (4S,4'S)-2,2'-环亚戊基双[4,5-二氢-4-苯基噁唑] | 1639791-77-7 | 9075822 |
| (4S,4'S,5R,5'R)-2,2'-(1-Methylethylidene)bis[4,5-dihydro-4,5-diphenyloxazole], 97%, ee: 98% (4S,4'S,5R,5'R)-2,2'-(1-甲基亚乙基)双[4,5-二氢-4,5-二苯基噁唑] | 157825-96-2 | 9108707 |
| (4R,4'R)-2,2'-Cyclopentylidenebis[4,5-dihydro-4-isopropyloxazole], 97%, ee: 98% (4R,4'R)-2,2'-环戊亚基双[4,5-二氢-4-异丙基噁唑] | 1379452-53-5 | 9188731 |
| (4S,4'S)-2,2'-Cyclohexylidenebis[4,5-dihydro-4-isopropyloxazole], 97%, ee: 98% (4S,4'S)-2,2'-环已亚基双[4,5-二氢-4-异丙基噁唑] | 1373357-00-6 | 9188734 |
| (4S,4'S)-2,2'-Cyclohexylidenebis[4,5-dihydro-4-(phenylmethyl)oxazole], 97%, ee: 98% (4S,4'S)-2,2'-环己亚基双[4,5-二氢-4-苯甲基噁唑] | 1003886-07-4 | 9188730 |
| 1,3-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)benzene, 98%, ee: ≥99% 1,3-双((S)-4-苯基-4,5-二氢恶唑-2-基)苯 | 876953-19-4 | 9263713 |
| (3aR,3'aR,8aS,8'aS)-2,2'-[2-Phenyl-1-(phenylmethyl)ethylidene]bis[3a,8a-dihydro-8H-Indeno[[1,2-d]oxazole (3aR,3'aR,8aS,8'aS)-2,2'-(2-苯基-1-苄基亚乙基)双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑 | 394738-76-2 | 205193 |
| (1Z,3Z)-1,3-Bis[[[(4S)-4,5-dihydro-4-(tert-butyl)-2-oxazolyl]methylene]-2,3-dihydro-1H-isoindole (1Z,3Z)-1,3-双[[[(4S)-4,5-二氢-4-叔丁基-2-恶唑基]亚甲基]-2,3-二氢-1H-异吲哚 | 1361563-41-8 | 200352 |
| (4S,?4'S)?-2,?2'-?Cyclopropylidenebis[?4,?5-?dihydro-?4-?(phenylmethyl)?oxazole] (4S,?4'S)?-2,?2'-?环丙亚基双[4,?5-?二氢-?4-苯甲基恶唑] | 1003886-01-8 | 200057 |
| (3aS,8aR)-3a,8a-Dihydro-2-(6-phenyl-2-pyridinyl)-8H-Indeno[1,2-d]oxazole (3aS,8aR)-3a,8a-二氢-2-(6-苯基-2-吡啶)-8H-茚并[1,2-d]恶唑 | 2634687-79-7 | 204578 |
PHOX系列(手性膦-噁唑啉)
| 品名 | CAS | 货号 |
|---|---|---|
| (R)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline, 98%, ee: 99% (R)-4-叔丁基-2-[2-(二苯基膦基)苯基]-2-噁唑啉 | 164858-79-1 | 1438790 |
| (S)-(-)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline, 97% (S)-(-)-2-[2-二苯基膦]苯基]-4-异丙基-2-噁唑啉 | 148461-14-7 | 177081 |
| (S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline, 97% (S)-4-叔丁基-2-[2-(二苯基膦基)苯基]-2-噁唑啉 | 148461-16-9 | 807430 |
| (S)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline, 97% (S)-(+)-2-[2-(二苯基膦)苯基]-4-苯基-2-噁唑啉 | 148461-15-8 | 302583 |
相关产品
超干溶剂
| 品名 | CAS | 货号 |
|---|---|---|
| Tetrahydrofuran, 99.9%, SuperDry, stabilized with 250 ppm BHT, Water≤50 ppm, J&KSeal 四氢呋喃 | 109-99-9 | 315353促 危化品 |
| Acetonitrile, 99.9%, SuperDry, with molecular sieves, water≤50 ppm, J&KSeal 乙腈 | 75-05-8 | 939631促 危化品 |
| 1,2-Dichloroethane, 99.5%, SuperDry, water≤30 ppm, J&Kseal 1,2-二氯乙烷 | 107-06-2 | 991050促 危化品 |
| 1,4-Dioxane, 99.5%, SuperDry, with molecular sieves, stabilized with BHT, J&Kseal, water≤50 ppm 1,4-二氧六环 | 123-91-1 | 972869促 危化品 |
核磁检测试剂
| 品名 | CAS | 货号 |
|---|---|---|
| Dimethyl sulfoxide-d6, 99.8 atom%D, contains 0.03% v/v TMS 氘代二甲基亚砜-d6 | 2206-27-1 | 182473促 |
| Chloroform-d, 99.8 atom%D, contains 0.03% v/v TMS, packed in 10*0.6 ml ampoules 氘代氯仿 | 865-49-6 | 240987促 |
| Tetrahydrofuran-d8, 99.5 atom%D 氘代四氢呋喃-d8 | 1693-74-9 | 247731 |
| Acetonitrile-d3, 99.8 atom%D 氘代乙腈-d3 | 2206-26-0 | 236920促 |
| Dichloromethane-d2, 99.8 atom%D 氘代二氯甲烷 | 1665-00-5 | 334919促 |
| Methanol-d4, 99.8 atom%D 氘代甲醇-d4 | 811-98-3 | 114655促 |
耗材
| 品名 | CAS | 货号 |
|---|---|---|
| TLC silica gel plate (fluorescent indicator), GF254, layer thickness 0.2-0.25 mm, 100*100 mm, 80 pcs/pack 薄层色谱硅胶板(含荧光) | / | 983347 |
| Silica, powder, 200 mesh 硅胶 | 112945-52-5 | 227600 |
| Spotting capillary tube, I.D.:0.3mm, Length:100mm, 1000pcs/pack 玻璃点样毛细管 | / | 2734477 |
| 5 mm NMR Economy Sample Tube w/ Cap, 7″, High-Throughput 5毫米,高通量经济型核磁管,7英寸 | / | 1001281 |
| Digital stainless steel hotplate magnetic stirrer, with heating, heating temperature range: RT 340℃, power 550 W 数显不锈钢加热磁力搅拌器 | / | 1122416 |
| Magnetic stir bar, PTFE-coated, egg-shaped, A100 (6*10mm), 5 pcs/pack 聚四氟乙烯磁力搅拌子,椭圆型 | / | 1482821 |
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