【新品上架】手性 1,4 - 二羰基砌块系列 —— 一步构建全碳季碳中心！
2026-10-12 · 推荐产品 · 百灵威授权转载
1,4 - 二羰基是构建呋喃、吡咯、内酯、内酰胺等杂环的核心前体，也是天然产物与药物分子中常见的骨架结构。然而，带有手性羟基和无环全碳季碳中心的 1,4 - 二羰基，因空间位阻大、选择性难控制，一直是合成化学的难点 —— 传统方法多依赖手性拆分或金属催化，存在收率低、重金属残留、底物适应性窄等问题，且商品化试剂种类极少，科研人员往往需自行摸索路线，耗时数月才能获得合格样品。
现在，百灵威提供 33 款高对映纯手性 1,4 - 二羰基化合物，即买即用。
产品核心优势
1. 高对映纯度：全部产品 ee 值 ≥ 97%，多数达 99% ee。
2. 一步构建全碳季碳手性中心：产品直接带有无环全碳季碳手性骨架，最高 99% 收率、8:1 非对映选择性、99% 对映选择性。
3. 无金属残留，绿色医药友好：适配医药研发与 GMP 前置探索，符合制药工业合规趋势。
应用场景
• 维生素 B5 及类似物合成
• 非天然手性氨基酸制备
• 药物中间体与天然产物合成
• 杂环化合物构建
• 不对称催化方法学研究
产品列表
| 品名 | CAS | 货号 |
|---|---|---|
| (S)-Ethyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate, ee≥99% (S)-2-羟基-3,3-二甲基-4-氧代丁酸乙酯 | / | 9755245 |
| (S)-Methyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate, ee≥99% (S)-2-羟基-3,3-二甲基-4-氧代丁酸甲酯 | / | 9755246 |
| (S)-Tert-butyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate, ee≥98% (S)-2-羟基-3,3-二甲基-4-氧代丁酸叔丁酯 | / | 9755247 |
| (S)-Ethyl 2-(1-formylcyclopentyl)-2-hydroxyacetate, ee≥99% (S)-2-(1-甲酰基环戊基)-2-羟基乙酸乙酯 | / | 9755248 |
| (S)-Ethyl 2-(1-formylcyclohexyl)-2-hydroxyacetate, ee≥97% (S)-2-(1-甲酰基环己基)-2-羟基乙酸乙酯 | / | 9755249 |
| (S)-Ethyl 3-ethyl-3-formyl-2-hydroxypentanoate, ee≥99% (S)-3-乙基-3-甲酰基-2-羟基戊酸乙酯 | / | 9755250 |
| (S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-phenylbutanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-氧代-4-苯基丁醛 | / | 9755251 |
| (S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-(o-tolyl)butanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-氧代-4-(邻甲苯基)丁醛 | / | 9755252 |
| (S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-(m-tolyl)butanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-氧代-4-(间甲苯基)丁醛 | / | 9755253 |
| (S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-(p-tolyl)butanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-氧代-4-(对甲苯基)丁醛 | / | 9755254 |
| (S)-4-(4-Fluorophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(4-氟苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755255 |
| (S)-4-(2-Chlorophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(2-氯苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755256 |
| (S)-4-(3-Chlorophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(3-氯苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755257 |
| (S)-4-(4-Chlorophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(4-氯苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755258 |
| (S)-4-(4-Bromophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(4-溴苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755259 |
| (S)-3-Hydroxy-4-(3-methoxyphenyl)-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-3-羟基-4-(3-甲氧基苯基)-2,2-二甲基-4-氧代丁醛 | / | 9755260 |
| (S)-3-Hydroxy-4-(4-methoxyphenyl)-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-3-羟基-4-(4-甲氧基苯基)-2,2-二甲基-4-氧代丁醛 | / | 9755261 |
| (S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-(4-(trifluoromethyl)phenyl)butanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-氧代-4-(4-三氟甲基苯基)丁醛 | / | 9755262 |
| (S)-4-([1,1'-Biphenyl]-4-yl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-([1,1'-联苯]-4-基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755263 |
| (S)-4-(2,4-Dichlorophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(2,4-二氯苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755264 |
| (S)-4-(3-Bromo-4-fluorophenyl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(3-溴-4-氟苯基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755265 |
| (S)-3-Hydroxy-4-mesityl-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-3-羟基-4-均三甲苯基-2,2-二甲基-4-氧代丁醛 | / | 9755266 |
| (S)-3-Hydroxy-2,2-dimethyl-4-(naphthalen-1-yl)-4-oxobutanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-(萘-1-基)-4-氧代丁醛 | / | 9755267 |
| (S)-3-Hydroxy-2,2-dimethyl-4-(naphthalen-2-yl)-4-oxobutanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-(萘-2-基)-4-氧代丁醛 | / | 9755268 |
| (S)-4-(Furan-2-yl)-3-hydroxy-2,2-dimethyl-4-oxobutanal, ee≥99% (S)-4-(呋喃-2-基)-3-羟基-2,2-二甲基-4-氧代丁醛 | / | 9755269 |
| (S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-(thiophen-2-yl)butanal, ee≥99% (S)-3-羟基-2,2-二甲基-4-氧代-4-(噻吩-2-基)丁醛 | / | 9755270 |
| (S,E)-3-Hydroxy-2,2-dimethyl-4-oxo-6-phenylhex-5-enal, ee≥98% (S,E)-3-羟基-2,2-二甲基-4-氧代-6-苯基己-5-烯醛 | / | 9755271 |
| (S)-3-Hydroxy-6-(4-methoxyphenyl)-2,2-dimethyl-4-oxohexanal, ee≥98% (S)-3-羟基-6-(4-甲氧基苯基)-2,2-二甲基-4-氧代己醛 | / | 9755272 |
| (S)-1-(2-(4-Fluorophenyl)-1-hydroxy-2-oxoethyl)cyclopentanecarbaldehyde, ee≥99% (S)-1-(2-(4-氟苯基)-1-羟基-2-氧代乙基)环戊基甲醛 | / | 9755273 |
| (S)-1-(2-(4-Fluorophenyl)-1-hydroxy-2-oxoethyl)cyclohexanecarbaldehyde, ee≥99% (S)-1-(2-(4-氟苯基)-1-羟基-2-氧代乙基)环己基甲醛 | / | 9755274 |
相关产品
超干溶剂
| 品名 | CAS | 货号 |
|---|---|---|
| Acetonitrile, 99.9%, SuperDry, with molecular sieves, water≤50 ppm, J&KSeal 乙腈 | 75-05-8 | 939631促 危化品 |
| Ethyl acetate, 99.5%, SuperDry, Water≤50 ppm, J&KSeal 乙酸乙酯 | 141-78-6 | 954403促 危化品 |
| N,N-Dimethylacetamide, 99.8%, SuperDry, with molecular sieves, Water≤50 ppm, J&KSeal N,N-二甲基乙酰胺 | 127-19-5 | 926412 |
| 1,4-Dioxane, 99.5%, SuperDry, with molecular sieves, stabilized with BHT, J&Kseal, water≤50 ppm 1,4-二氧六环 | 123-91-1 | 972869促 危化品 |
| Tetrahydrofuran, 99.9%, SuperDry, stabilized with 250 ppm BHT, Water≤50 ppm, J&KSeal 四氢呋喃 | 109-99-9 | 315353促 危化品 |
| 1,2-Dichloroethane, 99.5%, SuperDry, water≤30 ppm, J&Kseal 1,2-二氯乙烷 | 107-06-2 | 991050促 危化品 |
核磁检测试剂
| 品名 | CAS | 货号 |
|---|---|---|
| Dimethyl sulfoxide-d6, 99.8 atom%D, contains 0.03% v/v TMS 氘代二甲基亚砜-d6 | 2206-27-1 | 182473促 |
| Chloroform-d, 99.8 atom%D, contains 0.03% v/v TMS, packed in 10*0.6 ml ampoules 氘代氯仿 | 865-49-6 | 240987促 |
| Tetrahydrofuran-d8, 99.5 atom%D 氘代四氢呋喃-d8 | 1693-74-9 | 247731 |
| Acetonitrile-d3, 99.8 atom%D 氘代乙腈-d3 | 2206-26-0 | 236920促 |
| Dichloromethane-d2, 99.8 atom%D 氘代二氯甲烷 | 1665-00-5 | 334919促 |
| Methanol-d4, 99.8 atom%D 氘代甲醇-d4 | 811-98-3 | 114655促 |
耗材
| 品名 | CAS | 货号 |
|---|---|---|
| TLC silica gel plate (fluorescent indicator), GF254, layer thickness 0.2-0.25 mm, 100*100 mm, 80 pcs/pack 薄层色谱硅胶板(含荧光) | / | 983347 |
| Silica, powder, 200 mesh 硅胶 | 112945-52-5 | 227600 |
| Spotting capillary tube, I.D.:0.3mm, Length:100mm, 1000pcs/pack 玻璃点样毛细管 | / | 2734477 |
| 5 mm NMR Economy Sample Tube w/ Cap, 7″, High-Throughput 5毫米，高通量经济型核磁管，7英寸 | / | 1001281 |
| Digital stainless steel hotplate magnetic stirrer, with heating, heating temperature range: RT 340℃, power 550 W 数显不锈钢加热磁力搅拌器 | / | 1122416 |
| Magnetic stir bar, PTFE-coated, egg-shaped, A100 (6*10mm), 5 pcs/pack 聚四氟乙烯磁力搅拌子,椭圆型 | / | 1482821 |
参考文献
- Zhi-Hong Du, Bao-Xiu Tao, Meng Yuan, Wen-Juan Qin, Yan-Li Xu, Pei Wang, Chao-Shan Da; Peptide-Catalyzed Highly Asymmetric Cross-Aldol Reaction of Aldehydes to Biomimetically Synthesize 1,4-Dicarbonyls. Org. Lett. 5 June 2020; 22 (11): 4444–4450.
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