多糖结合疫苗生产全流程核心原料解决方案
2026-07-06 · 产品方案 · 百灵威授权转载
多糖结合疫苗是预防肺炎球菌、脑膜炎球菌、b型流感嗜血杆菌（Hib）等荚膜细菌感染的最有效手段，通过将细菌荚膜多糖共价结合到载体蛋白上，成功将T细胞非依赖性抗原转化为T细胞依赖性抗原，从而诱导持久的免疫记忆和高亲和力抗体。
百灵威拥有先进的研发、制造与整合能力，提供覆盖多糖结合疫苗生产全流程的关键原辅料，涵盖细菌发酵与培养、多糖提取与纯化、多糖活化与衍生化、载体蛋白表达与纯化、多糖-蛋白偶联与纯化、制剂与佐剂、质量控制与检测等各个环节，助力疫苗企业高效、稳定地实现从研发到商业化生产的转化。
产品优势
- 全流程产品覆盖：提供超过300种原辅料，从培养基组分、活化/偶联试剂到层析填料、佐剂及检测试剂盒，满足一站式采购需求；
- 拥有独立的合成技术，研发能力值得信赖；
- 严格的质控体系：采用多种分析手段进行纯度、活性、内毒素等检测，确保批次间稳定性，符合疫苗生产的严苛要求；
- 灵活供应能力：具备大包装供应能力，支持工业化规模生产；
- 极具竞争力的价格：通过自主生产与供应链优化，提供高性价比的产品；
- 现货充足，快速响应。
产品列表
细菌培养与发酵
| 品名 | CAS | 货号 |
|---|---|---|
| Brain heart extract broth (BHI) 脑心浸出液肉汤 (BHI) | / | 9301252 |
| 脑心浸液琼脂(BHI) 脑心浸液琼脂(BHI) | / | LA0680-100g |
| Peptone from soya 大豆蛋白胨 | 91079-46-8 | 1268715 |
| Yeast extract powder 酵母提取粉 | 8013-01-2 | 716769 |
| D-(+)-Glucose, 99%, for bio D-(+)-葡萄糖 | 50-99-7 | 936778促 |
| Peptone 蛋白胨 | 73049-73-7 | 146972 |
| L-Glutamine, 99%, reagent grade L-谷氨酰胺 | 56-85-9 | 333722 |
| L-Leucine, 99% L-亮氨酸 | 61-90-5 | 235041 |
| Sodium phosphate dibasic, 99%, AR 无水磷酸氢二钠 | 7558-79-4 | 963186 |
| Ammonium sulfate, 99%, AR 硫酸铵 | 7783-20-2 | 981713 |
| Ammonium chloride, 99.5%, AR 氯化铵 | 12125-02-9 | 980615 |
| Potassium dihydrogen phosphate, 99.5%, for analysis 磷酸二氢钾 | 7778-77-0 | 986107 |
| Sodium phosphate dibasic, 99%, AR 无水磷酸氢二钠 | 7558-79-4 | 963186 |
| β-Propiolactone, 98%, research grade β-丙内酯 | 57-57-8 | 996513 |
| Glycerol, 99%, for analysis 甘油 | 56-81-5 | 945126 |
多糖提取与纯化
| 品名 | CAS | 货号 |
|---|---|---|
| Hexadecyltrimethylammonium bromide, 99% 十六烷基三甲基溴化铵 | 57-09-0 | 192496 |
| Phenol, 99.5% 苯酚 | 108-95-2 | 912060 危化品 |
| Trichloroacetic acid, 99%, ACS reagent 三氯乙酸 | 76-03-9 | 519758 危化品 |
| Sodium deoxycholate, 97%, for bio 去氧胆酸钠 | 302-95-4 | 927090 |
| Triton X-100, 98%, for molecular biology 曲拉通 X-100 | 9002-93-1 | 993361 |
| Tween 80 吐温 80 | 9005-65-6 | 437595 |
| Deoxyribonuclease I, from bovine pancreas, ≥2000 Kunitz U/mg 脱氧核糖核酸酶 I | 9003-98-9 | 231871 |
| Ribonuclease A, ≥50 Kunitz units/mg 核糖核酸酶 A | 9001-99-4 | 967022 |
| Proteinase K, for bio, 30-40U/mg 蛋白酶 K | 39450-01-6 | 968706 |
| Benzonase 全能核酸酶 | 9025-65-4 | S26578 |
| Isopropanol, 99.7%, for analysis 异丙醇 | 67-63-0 | 928086 危化品 |
| Anhydrous ethanol, 99.7%, AR 无水乙醇 | 64-17-5 | 904283 危化品 |
| Sodium acetate, 99%, AR 无水醋酸钠 | 127-09-3 | 975558 |
| Sephadex G-25, 20 - 80 μm 葡聚糖凝胶G-25 | 9041-35-4 | 975520 |
| Phosphate buffered saline solution (10×PBS, calcium and magnesium free) 磷酸缓冲盐溶液(10×PBS,无钙镁) | / | 9456171 |
| Phosphate buffered saline powder (1×PBS, calcium and magnesium free) 磷酸缓冲盐粉剂(1×PBS,无钙镁) | / | 9456169 |
多糖活化与衍生化
| 品名 | CAS | 货号 |
|---|---|---|
| 1-Cyano-4-(dimethylamino)pyridinium tetrafluoroborate, 98% 1-氰基-4-(二甲基氨基)吡啶鎓四氟硼酸盐 | 59016-56-7 | 559768 |
| Cyanogen bromide, 97%, for synthesis 溴化氰 | 506-68-3 | 173639 危化品 |
| Sodium periodate, 99%, for synthesis 高碘酸钠 | 7790-28-5 | 974859 危化品 |
| 1,4-Butanediol diglycidyl ether, 98.5% 1,4-丁二醇二缩水甘油醚 | 2425-79-8 | 968253 |
| N,N'-Carbonyldiimidazole, 98%, for synthesis N,N'-羰基二咪唑 | 530-62-1 | 947484 |
| Epichlorohydrin, 99.85%, for synthesis 环氧氯丙烷 | 106-89-8 | 467134 危化品 |
| N,N'-Disuccinimidyl carbonate, 99%, reagent grade N.N'-二琥珀酰亚胺基碳酸酯 | 74124-79-1 | 992431 |
| Periodic acid, 99%, AR 高碘酸 | 10450-60-9 | 964229 危化品 |
多糖-蛋白偶联
| 品名 | CAS | 货号 |
|---|---|---|
| N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, 98% N-(3-二甲基氨基丙基)-N'-乙基碳二亚胺 盐酸盐 | 25952-53-8 | 978717新 |
| 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 97%, for synthesis 1-(3-二甲氨基丙基)-3-乙基碳二亚胺 | 1892-57-5 | 963053 |
| N-Hydroxysuccinimide, 98%, for synthesis N-羟基琥珀酰亚胺 | 6066-82-6 | 903973 |
| N-Hydroxysulfosuccinimide sodium salt, 98% N-羟基磺酰基琥珀酰亚胺钠盐 | 106627-54-7 | 183144促 |
| Sodium cyanoborohydride, 97% 氰基硼氢化钠 | 25895-60-7 | 987731 |
| Sodium triacetoxyborohydride, 97%, for synthesis 三乙酰氧基硼氢化钠 | 56553-60-7 | 959366 |
| Adipic acid dihydrazide, 98% 己二酸二酰肼 | 1071-93-8 | 202233 |
| 6-Aminohexanoic acid, 98.5% 6-氨基己酸 | 60-32-2 | 145815 |
| 1,6-Hexanediamine, 99.5% 1,6-己二胺 | 124-09-4 | 901510 危化品 |
| DL-Dithiothreitol, 99%, for molecular biology DL-二硫苏糖醇 | 3483-12-3 | 926470 |
| L-Glutathione, 99%, for analysis, reduced L-谷胱甘肽 | 70-18-8 | 387160 |
| N,N-Dimethylformamide, 99.9%, for synthesis N,N-二甲基甲酰胺 | 68-12-2 | 914616 危化品 |
制剂与佐剂
| 品名 | CAS | 货号 |
|---|---|---|
| D-Lactose, 98%, reference material D-乳糖 | 63-42-3 | 959240 |
| D-(+)-Sucrose, 99%, for bio D-(+)-蔗糖 | 57-50-1 | 958990 |
| D-(+)-Trehalose, 99%, anhydrous D-(+)-海藻糖 | 99-20-7 | 242508 |
| Albumin from human serum, 96% 人血清白蛋白 | 70024-90-7 | 601386 |
| Gelatin, for analysis, From pigskin 明胶 | 9000-70-8 | 918970 |
| Alum adjuvant, PDI: 0.13 纳米级氢氧化铝佐剂 | 21645-51-2 | 921101 |
| Alum adjuvant, Particle Size: 3 μm 微米级氢氧化铝佐剂 | 21645-51-2 | 942729 |
| Aluminium phosphate adjuvant L-磷酸铝佐剂 | 7784-30-7 | 986987 |
| Bovine serum albumin, 98%, Australia origin, low IgG, low fatty acid 牛血清白蛋白 | 9048-46-8 | 109636 |
| Bovine serum albumin, 98%, from bovine serum 牛血清白蛋白 | 9048-46-8 | 900523 |
| Thimerosal, 98% 硫柳汞钠 | 54-64-8 | 273539 危化品 |
| Sodium benzoate, 99% 苯甲酸钠 | 532-32-1 | 259476 |
| 2-Phenoxyethanol, 99.5% 2-苯氧基乙醇 | 122-99-6 | 944152 |
| Phenol, 99% 苯酚 | 108-95-2 | 919590 危化品 |
| Mercury(II) sulfate, 99%, AR 硫酸汞 | 7783-35-9 | 168302 危化品 |
| Citric acid sodium citrate powder, 10 mmol/L, pH 6.0 柠檬酸—柠檬酸钠粉剂 | / | 9456172 |
制剂与冻干
| 品名 | CAS | 货号 |
|---|---|---|
| Alum adjuvant, Particle Size: 3 μm 微米级氢氧化铝佐剂 | 21645-51-2 | 942729 |
| Alum adjuvant, PDI: 0.13 纳米级氢氧化铝佐剂 | 21645-51-2 | 921101 |
| Aluminium phosphate adjuvant L-磷酸铝佐剂 | 7784-30-7 | 986987 |
| L-MF59 L-MF59佐剂 | / | 9401099 |
| L-AS03 L-AS03佐剂 | / | 9401100 |
| Albumin from human serum, 96% 人血清白蛋白 | 70024-90-7 | 601386 |
| D-(+)-Trehalose, 99%, anhydrous D-(+)-海藻糖 | 99-20-7 | 242508 |
| D-Mannitol, 98% D-甘露醇 | 69-65-8 | 351126 |
| Gelatin, for analysis, From pigskin 明胶 | 9000-70-8 | 918970 |
| L-Arginine, 99% L-精氨酸 | 74-79-3 | 118040 |
| Thimerosal, 98% 硫柳汞钠 | 54-64-8 | 273539 危化品 |
| P300 P300抑菌防腐剂 | / | 991043促 |
| Sodium benzoate, 99% 苯甲酸钠 | 532-32-1 | 259476 |
| 2-Phenoxyethanol, 99.5% 2-苯氧基乙醇 | 122-99-6 | 944152 |
| Phenol, 99% 苯酚 | 108-95-2 | 919590 危化品 |
| Tween 80 吐温 80 | 9005-65-6 | 437595 |
| Tris(hydroxymethyl)aminomethane, 99.5%, extra pure 三(羟甲基)氨基甲烷 | 77-86-1 | 226162 |
| Citric acid sodium citrate powder, 10 mmol/L, pH 6.0 柠檬酸—柠檬酸钠粉剂 | / | 9456172 |
质量控制与检测
| 品名 | CAS | 货号 |
|---|---|---|
| CHO细胞宿主蛋白(CHOHCP)ELISA科研试剂盒 CHO细胞宿主蛋白(CHOHCP)ELISA科研试剂盒 | / | JM-06010O1 |
| CHO宿主细胞DNA残留检测试剂盒（荧光PCR法）冻存管；25T；3管/盒 CHO宿主细胞DNA残留检测试剂盒（荧光PCR法）冻存管；25T；3管/盒 | / | BNCC370235 |
| BCA(Bicinchoninic Acid)蛋白定量试剂盒 BCA(Bicinchoninic Acid)蛋白定量试剂盒 | / | BCA1 |
| 硫乙醇酸盐流体培养基 硫乙醇酸盐流体培养基 | / | RL100110-15*300ml |
| 硫乙醇酸盐流体培养基（颗粒） 硫乙醇酸盐流体培养基（颗粒） | / | LB1700-250g |
| 胰酪大豆胨液体培养基(输液瓶)(压盖)(药典) 胰酪大豆胨液体培养基(输液瓶)(压盖)(药典) | / | RL100111-40*100ml |
| 支原体检测试剂盒 支原体检测试剂盒 | / | CA1080-100T |
| Trifluoroacetic acid, 99.9% 三氟乙酸 | 76-05-1 | 101398 危化品 |
| SAX-NP5 HPLC column, 4.6mm×250mm, 5 μm 强阴离子交换液相色谱柱SAX-NP5 | / | 2666550 |
| BioSep SEC PMA-MC10 HPLC column, 300×7.8 mm 10μm, 500Å 体积排阻生物分离柱 | / | 9337501 |
通用实验室耗材
| 品名 | CAS | 货号 |
|---|---|---|
| 超滤离心管 超滤离心管 | / | U639195 |
| T25 cm² TC cell culture flask, Sterilized bagged, red vented cap, 12 tips/pack, 25 packs/case T25c㎡ TC细胞培养瓶 | / | 9451981 |
| 2mL Pipette, Easy to tear paper plastic packaging, 50 tips/pack, 20 packs/case 2mL移液管 | / | 9452035 |
| 250mL PP Conical-bottom centrifuge bottle, Sterilized baggeds, orange sealed cap, 6 tips/pack, 102 tips/case 250mL PP锥底离心瓶 | / | 9452043 |
| 5-layer ADsurface cell factory, Double-layer sterilized packs, green breathable cap, 1 tips/pack, 10 packs/case 5层ADsurface细胞工厂 | / | 9452049 |
| 96-well non-removable high-binding ELISA plate, Bagged, black with lid, 25 tips/box, 4 boxes/case 96孔不可拆高结合力酶标板 | / | 9478548 |
| 96-well removable high-binding ELISA plate, Bagged, white without lid, white frame, 5 tips/bag, 20 bags/case 96孔可拆卸高结合力酶标板 | / | 9478551 |
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