【新品速递】SadPhos配体家族上线！一“体”多能，解锁不对称催化新可能
2026-05-06 · 推荐产品 · 百灵威授权转载
在不对称催化领域，Sadphos配体家族正凭借其独特的设计理念与卓越性能，成为解决手性合成难题的“利器”。该系列配体由复旦大学张俊良教授课题组自主研发，名称源于亚磺酰胺膦配体英文名Sulfinamide Phosphine的简称。Sadphos是一类新型手性膦配体，其核心优势在于“非C2对称性”、“刚柔并济”与“软硬兼施”的巧妙结合，使其具备出色的自适应配位能力。
SadPhos 的核心优势
1. 适用范围极广：已成功应用于金、铜、镍、钯、钴、铑、铱、银等 8 种过渡金属催化的 50 余种不对称反应。
2. 自适应配位：分子中同时含有 P、N、S、O 等多个配位原子，可根据底物和金属价态变化在催化循环中动态切换配位模式（P,O-双齿 / P-单齿），兼顾高活性和高选择性。
3. 既是配体又是催化剂：可作为高效的手性有机小分子催化剂，在 Rauhut-Currier 等反应中表现优异。
为助力前沿手性合成研究，百灵威现推出Sadphos配体家族系列产品，为您的不对称催化反应提供多样化的“利器”选择！
Sadphos配体
| 品名 | CAS | 货号 |
|---|---|---|
| [S(R)]-N-[(1S)-1-[[2-(Diphenylphosphino)phenyl]-2,2-dimethylpropyl]-2-methyl-2-propanesulfinamide, 95% [S(R)]-N-[(1S)-1-[[2-(二苯基膦)苯基]-2,2-二甲丙基]-2-叔丁基亚磺酰胺 | 1595319-94-0 | 9184499 |
| N-[(1S)-(1-Ferrocenyl)-2-(diphenylphosphino)ethyl)]-3,5-bis(trifluoromethyl)-benzamide, 95% N-[(1S)-1-二茂铁-2-(二苯基膦)乙基]-3,5-二(三氟甲基)苯甲酰胺 | 2131816-17-4 | 9184569 |
| [S(R)]-N-[(S)-[[3,5-Bis(trifluoromethyl)phenyl][2-(diphenylphosphino)phenyl]methyl]-2-methyl-2-propanesulfinamide, 95% [S(R)]-N-[(S)-[[3,5-二(三氟甲基)苯基][2-(二苯基膦)苯基]甲基]-2-叔丁基亚磺酰胺 | 2262535-73-7 | 9184571 |
| [S(R)]-N-[(1S)-1-[[2-(Di-tert-butylphosphanyl)phenyl]-2,2-dimethylpropyl]-2-methyl-2-propanesulfinamide, 95% [S(R)]-N-[(1S)-1-[[2-(二叔丁基膦)苯基]-2,2-二甲丙基]-2-叔丁基亚磺酰胺 | 2565792-66-5 | 9219596 |
| [S(R)]-N-[(R)-[[2-(Diphenylphosphino)phenyl](2-naphthalenyl)methyl]-2-methyl-2-propanesulfinamide, 95% [S(R)]-N-[(R)-[[2-(二苯基膦)苯基](2-萘基)甲基]-2-叔丁基亚磺酰胺 | / | 9222882 |
| [S(R)]-N-((S)-(2-(Diphenylphosphino)phenyl)(2,4,6-triisopropylphenyl)methyl)-2-methyl-2-propanesulfinamide, 95% [S(R)]-N-[(S)-[[2-(二苯基膦)苯基](2,4,6-三异丙基苯基)甲基]-2-叔丁基亚磺酰胺 | / | 9222883 |
| [S(R)]-N-[(R)-(4-(tert-Butyl)phenyl)[[2-(diphenylphosphino)phenyl]methyl]-N,2-dimethyl-2-propanesulfinamide, 95% [S(R)]-N-[(R)-(4-叔丁基苯基)[[2-(二苯基膦)苯基]甲基]-N-甲基-2-叔丁基亚磺酰胺 | / | 9222887 |
| [S(R)]-N-[(R)-[[2-(Dicyclohexylphosphanyl)phenyl](4-(tert-butyl)phenyl)methyl]-N,2-dimethyl-2-propanesulfinamide, 95% [S(R)]-N-[(R)-[[2-(二环己基膦)苯基](4-叔丁基苯基)甲基]-N-甲基-2-叔丁基亚磺酰胺 | 2565792-61-0 | 9222896 |
| [S(R)]-N-[(S)-[[3,5-Di-tert-butyl-4-methoxyphenyl][5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]methyl]-2-methyl-2-propanesulfinamide, 95% [S(R)]-N-[(S)-[[3,5-二叔丁基-4-甲氧基苯基][5-(二苯基膦)-9,9-二甲基-9H-氧杂蒽]甲基]-2-叔丁基亚磺酰胺 | 2565792-28-9 | 9222901 |
金属催化剂
| 品名 | CAS | 货号 |
|---|---|---|
| Tetrakis(triphenylphosphine)palladium(0), 99% 四(三苯基膦)钯(0) | 14221-01-3 | 182482 |
| Chlorotriphenylphosphinegold(I), 98% 三苯基膦氯化金(I) | 14243-64-2 | 406825 |
| Nickel(II) acetylacetonate, 96% 乙酰丙酮镍(II) | 3264-82-2 | 452325 |
| Copper(II) trifluoromethanesulfonate, 98%, for synthesis 三氟甲烷磺酸铜(II) | 34946-82-2 | 902922 |
| (Acetylacetonato)(1,5-cyclooctadiene)rhodium(I), 98% (1,5-环辛二烯)2,4-戊二酮铑(I) | 12245-39-5 | 928309 |
超干溶剂
| 品名 | CAS | 货号 |
|---|---|---|
| Tetrahydrofuran, 99.5%, SuperDry, with molecular sieves, stabilized with 250 ppm BHT, Water≤50 ppm, J&KSeal 四氢呋喃 | 109-99-9 | 974643促 危化品 |
| 1,4-Dioxane, 99.5%, SuperDry, with molecular sieves, stabilized with BHT, J&Kseal, water≤50 ppm 1,4-二氧六环 | 123-91-1 | 972869促 危化品 |
| 1,2-Dimethoxyethane, 99.5%, SuperDry, water≤30 ppm, J&KSeal 1,2-二甲氧基乙烷 | 110-71-4 | 961681促 危化品 |
| Xylenes, 99%, SuperDry, mixture of isomers, Water≤50 ppm, J&KSeal 二甲苯 | 1330-20-7 | 972646促 危化品 |
| Dichloromethane, 99.9%, SuperDry, stabilized with amylene, water≤30 ppm, J&KSeal 二氯甲烷 | 75-09-2 | 961203促 危化品 |
耗材
| 品名 | CAS | 货号 |
|---|---|---|
| Quantitative spotting capillary tubes, 1 μl, capacity error ±0.05 μl 定量点样毛细管 | / | 9219772 |
| TLC silica gel plate (fluorescent indicator), HPTLC, GF254, layer thickness 0.2-0.25 mm, 50*25 mm, 640 pcs/pack 薄层色谱硅胶板(含荧光) | / | 943013 |
| Transfer pipets, 3 ml, 160 mm, PE, capacity 7.5 ml, unsterile 吸管 | / | 989082 |
| Magnetic stir bar, PTFE-coated, egg-shaped, A200(8-9mm*20mm), 5 pcs/pack 聚四氟乙烯磁力搅拌子,椭圆型 | / | 978702 |
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不对称合成-手性化学的未来引擎
