刘国凯副教授科研成果 | 稳•多•广：一剂三优的二氟甲基锍盐试剂
2026-04-10 · 推荐产品 · 百灵威授权转载
在药物、农药及功能材料分子中引入二氟甲基（CF2H），可显著提升分子的代谢稳定性、脂溶性及生物利用度，是含氟分子设计与优化的关键策略之一。因此，高效、可控地实现二氟甲基化反应，成为有机氟化学与药物化学领域的核心研究课题。
然而，现有试剂在实际研发中长期存在稳定性差、模式单一、条件苛刻等问题，导致反应产率低、重复性差、适用范围窄，成为含氟分子研发的关键瓶颈。
深圳大学刘国凯副教授团队设计开发的亲电型二氟甲基锍盐试剂——S-(二氟甲基)-苯基-(2,4,6-三甲氧基苯基)硫鎓四氟硼酸盐，通过分子内氢键设计策略，从根本上解决了传统试剂稳定性差的问题，并在多个维度实现全面突破。
图1. 二氟甲基锍盐试剂的晶体结构、结构通式与形貌
产品核心优势
●超高稳定性：结晶性粉末，对空气/湿气不敏感。
●多模式反应：可实现•CF₂H、+CF₂H、:CF₂H三种活性物种的转化，覆盖自由基、亲电、卡宾等多种反应机制。
●底物适用范围广：适用于β-酮酯、醇、酚、异氰、烯烃等多种底物类型，满足不同研发场景需求。
●操作条件温和：常规实验室环境即可使用，适合高通量筛选和规模化应用
●平台型试剂定位：为二氟甲基化新策略、新方法开发提供高效实用的通用工具。
应用实例
见图2。
图2. 二氟甲基锍盐试剂的应用实例
产品列表
二氟甲基锍盐试剂 品名 CAS 货号 S-(Difluoromethyl) phenyl (2,4,6-trimethoxyphenyl) sulfonium tetrafluoroborate, 90%
S-(二氟甲基)-苯基-(2,4,6-三甲氧基苯基)硫鎓四氟硼酸盐 2247292-19-7 9617869
光催化剂 品名 CAS 货号 Tris(2-phenylpyridine)iridium, 99%, for synthesis
三(2-苯基吡啶)合铱 94928-86-6 997766
Tris(2,2'-bipyridyl)ruthenium(II)chloride hexahydrate, 98%
三(2,2’-联吡啶基)氯化钌(II)六水合物 50525-27-4 102033
溶剂 品名 CAS 货号 Fluorobenzene, 99%, for synthesis
氟苯 462-06-6 948533
危化品 Dichloromethane, 99.9%, SuperDry, with molecular sieves, water≤30 ppm, J&KSeal
二氯甲烷 75-09-2 908525促
危化品 Ethyl acetate, 99.5%, SuperDry, Water≤50 ppm, J&KSeal
乙酸乙酯 141-78-6 954403促
危化品
碱 品名 CAS 货号 Lithium hydroxide, 99%, anhydrous
氢氧化锂 1310-65-2 500019
危化品 Sodium hydride, for synthesis, 60%, dispersion in mineral oil
氢化钠 7646-69-7 961241
危化品 Potassium hydroxide, 85%, AR
氢氧化钾 1310-58-3 902618
危化品
添加剂 品名 CAS 货号 Poly(ethylene glycol), reagent grade, average Mn 600
聚乙二醇 25322-68-3 931173
耗材 品名 CAS 货号 Silica gel, 200-425 mesh
硅胶 112926-00-8 227599
Quantitative spotting capillary tubes, 1 μl, capacity error ±0.05 μl
定量点样毛细管 / 9219772
TLC silica gel plate (fluorescent indicator), GF254, layer thickness 0.2-0.25 mm, 100*100 mm, 80 pcs/pack
薄层色谱硅胶板(含荧光) / 983347
Magnetic stir bar, PTFE-coated, egg-shaped, A200(8-9mm*20mm), 5 pcs/pack
聚四氟乙烯磁力搅拌子,椭圆型 / 978702
More
参考文献
- Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of β-Ketoesters and Malonates, Org. Lett. 2018, 20, 6925-6929.
- Direct C(sp³)–H difluoromethylation via radical–radical cross-coupling by visible-light photoredox catalysis, Org. Chem. Front., 2022, 9, 2141−2148.
- Difluoromethyl Radical Triggered Tandem Reaction of N‑Allyl Amides to Difluoromethylated β‑Amino Alcohols by Photoredox Catalysis, Org. Lett. 2021, 23(21), 8482−8487.
- Facile difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt: reaction, scope and mechanistic study, Chem. Commun. 2019, 55, 7446-7449.
- Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl)sulfonium salt, Chin. Chem. Lett. 2019, 30,1515-1518.
- Visible-Light Photoredox-Catalyzed Three-Component Reaction of Carbazoles with Alkenes and S‑(Difluoromethyl)sulfonium Salt: A Practical Approach to Access Difluoroalkyl-Functionalized Carbazoles, J. Org. Chem. 2023, 88, 10711−10720.
- Facile Entry to Pharmaceutically Important 3-Difluoromethyl-Quinoxalin-2-Ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-Ones, Pharmaceuticals 2022, 15, 1552.
- Visible-Light-Driven Difluoromethylation of Isocyanides with S‑(Difluoromethyl)diarylsulfonium Salt: Access to a Wide Variety of Difluoromethylated Phenanthridines and Isoquinolines, J. Org. Chem. 2020, 85, 10479-10487.
- Difluoromethylation of Phenols and Thiophenols with the S-(Difluoromethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study, J. Org. Chem. 2019, 84, 15948-15957.
推荐阅读
有机氟化学——氟化物合成及转化常用产品，更有新型氟化试剂！
有机氟化合物合成通用试剂——二氟甲基(2-吡啶基)砜在药物领域的应用
有机氟化学——常用氟化试剂TMSCF3的应用及制备
S-(二氟甲基)-苯基-(2,4,6-三甲氧基苯基)硫鎓四氟硼酸盐
| 品名 | CAS | 货号 |
|---|---|---|
| Tris(2-phenylpyridine)iridium, 99%, for synthesis 三(2-苯基吡啶)合铱 | 94928-86-6 | 997766 |
| Tris(2,2'-bipyridyl)ruthenium(II)chloride hexahydrate, 98% 三(2,2’-联吡啶基)氯化钌(II)六水合物 | 50525-27-4 | 102033 |
溶剂 品名 CAS 货号 Fluorobenzene, 99%, for synthesis
氟苯 462-06-6 948533
危化品 Dichloromethane, 99.9%, SuperDry, with molecular sieves, water≤30 ppm, J&KSeal
二氯甲烷 75-09-2 908525促
危化品 Ethyl acetate, 99.5%, SuperDry, Water≤50 ppm, J&KSeal
乙酸乙酯 141-78-6 954403促
危化品
氟苯
危化品
二氯甲烷
危化品
乙酸乙酯
危化品
碱 品名 CAS 货号 Lithium hydroxide, 99%, anhydrous
氢氧化锂 1310-65-2 500019
危化品 Sodium hydride, for synthesis, 60%, dispersion in mineral oil
氢化钠 7646-69-7 961241
危化品 Potassium hydroxide, 85%, AR
氢氧化钾 1310-58-3 902618
危化品
氢氧化锂
危化品
氢化钠
危化品
氢氧化钾
危化品
添加剂 品名 CAS 货号 Poly(ethylene glycol), reagent grade, average Mn 600
聚乙二醇 25322-68-3 931173
耗材 品名 CAS 货号 Silica gel, 200-425 mesh
硅胶 112926-00-8 227599
Quantitative spotting capillary tubes, 1 μl, capacity error ±0.05 μl
定量点样毛细管 / 9219772
TLC silica gel plate (fluorescent indicator), GF254, layer thickness 0.2-0.25 mm, 100*100 mm, 80 pcs/pack
薄层色谱硅胶板(含荧光) / 983347
Magnetic stir bar, PTFE-coated, egg-shaped, A200(8-9mm*20mm), 5 pcs/pack
聚四氟乙烯磁力搅拌子,椭圆型 / 978702
More
参考文献
- Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of β-Ketoesters and Malonates, Org. Lett. 2018, 20, 6925-6929.
- Direct C(sp³)–H difluoromethylation via radical–radical cross-coupling by visible-light photoredox catalysis, Org. Chem. Front., 2022, 9, 2141−2148.
- Difluoromethyl Radical Triggered Tandem Reaction of N‑Allyl Amides to Difluoromethylated β‑Amino Alcohols by Photoredox Catalysis, Org. Lett. 2021, 23(21), 8482−8487.
- Facile difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt: reaction, scope and mechanistic study, Chem. Commun. 2019, 55, 7446-7449.
- Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl)sulfonium salt, Chin. Chem. Lett. 2019, 30,1515-1518.
- Visible-Light Photoredox-Catalyzed Three-Component Reaction of Carbazoles with Alkenes and S‑(Difluoromethyl)sulfonium Salt: A Practical Approach to Access Difluoroalkyl-Functionalized Carbazoles, J. Org. Chem. 2023, 88, 10711−10720.
- Facile Entry to Pharmaceutically Important 3-Difluoromethyl-Quinoxalin-2-Ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-Ones, Pharmaceuticals 2022, 15, 1552.
- Visible-Light-Driven Difluoromethylation of Isocyanides with S‑(Difluoromethyl)diarylsulfonium Salt: Access to a Wide Variety of Difluoromethylated Phenanthridines and Isoquinolines, J. Org. Chem. 2020, 85, 10479-10487.
- Difluoromethylation of Phenols and Thiophenols with the S-(Difluoromethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study, J. Org. Chem. 2019, 84, 15948-15957.
推荐阅读
有机氟化学——氟化物合成及转化常用产品，更有新型氟化试剂！
有机氟化合物合成通用试剂——二氟甲基(2-吡啶基)砜在药物领域的应用
有机氟化学——常用氟化试剂TMSCF3的应用及制备
聚乙二醇
| 品名 | CAS | 货号 |
|---|---|---|
| Silica gel, 200-425 mesh 硅胶 | 112926-00-8 | 227599 |
| Quantitative spotting capillary tubes, 1 μl, capacity error ±0.05 μl 定量点样毛细管 | / | 9219772 |
| TLC silica gel plate (fluorescent indicator), GF254, layer thickness 0.2-0.25 mm, 100*100 mm, 80 pcs/pack 薄层色谱硅胶板(含荧光) | / | 983347 |
| Magnetic stir bar, PTFE-coated, egg-shaped, A200(8-9mm*20mm), 5 pcs/pack 聚四氟乙烯磁力搅拌子,椭圆型 | / | 978702 |
参考文献
- Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of β-Ketoesters and Malonates, Org. Lett. 2018, 20, 6925-6929.
- Direct C(sp³)–H difluoromethylation via radical–radical cross-coupling by visible-light photoredox catalysis, Org. Chem. Front., 2022, 9, 2141−2148.
- Difluoromethyl Radical Triggered Tandem Reaction of N‑Allyl Amides to Difluoromethylated β‑Amino Alcohols by Photoredox Catalysis, Org. Lett. 2021, 23(21), 8482−8487.
- Facile difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt: reaction, scope and mechanistic study, Chem. Commun. 2019, 55, 7446-7449.
- Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl)sulfonium salt, Chin. Chem. Lett. 2019, 30,1515-1518.
- Visible-Light Photoredox-Catalyzed Three-Component Reaction of Carbazoles with Alkenes and S‑(Difluoromethyl)sulfonium Salt: A Practical Approach to Access Difluoroalkyl-Functionalized Carbazoles, J. Org. Chem. 2023, 88, 10711−10720.
- Facile Entry to Pharmaceutically Important 3-Difluoromethyl-Quinoxalin-2-Ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-Ones, Pharmaceuticals 2022, 15, 1552.
- Visible-Light-Driven Difluoromethylation of Isocyanides with S‑(Difluoromethyl)diarylsulfonium Salt: Access to a Wide Variety of Difluoromethylated Phenanthridines and Isoquinolines, J. Org. Chem. 2020, 85, 10479-10487.
- Difluoromethylation of Phenols and Thiophenols with the S-(Difluoromethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study, J. Org. Chem. 2019, 84, 15948-15957.
推荐阅读
有机氟化学——氟化物合成及转化常用产品，更有新型氟化试剂！有机氟化合物合成通用试剂——二氟甲基(2-吡啶基)砜在药物领域的应用
有机氟化学——常用氟化试剂TMSCF3的应用及制备
