细胞信号传导——JAK/STAT信号通路相关产品精选
2025-10-20 · 产品方案 · 百灵威授权转载
细胞信号传导是指细胞通过一系列复杂的生物化学反应，感知、转导并响应内外环境变化的基本生命过程。细胞信号传导是维持机体稳态、协调细胞行为、调控生长发育、应对环境变化、维持组织完整性的重要生命机制。其在疾病机制阐释、药物研发靶点、农业与生物技术具有重要应用。 JAK/STAT（Janus激酶/信号转导与转录激活子）信号通路是一条由细胞因子刺激的信号转导通路，广泛参与细胞增殖、分化、凋亡等重要生物学过程，通路异常会导致炎症性疾病、白血病及实体肿瘤等疾病。针对JAK/STAT通路的靶向治疗是当下热点，目前以JAK为靶点的药物已用于临床治疗类风湿关节炎和骨髓增生性疾病。
百灵威提供JAK/STAT信号通路中小分子抑制剂、激动剂等活性化合物。
靶点清晰明确，便于选择；
质检严格，确保产品高纯度、高品质；
活性高：生物活性经多客户验证
小分子抑制剂、激动剂等活性化合物
| 品名 | CAS | 货号 |
|---|---|---|
| Artesunate, 98%, an inhibitor of both STAT-3 and exported protein 1 (EXP1) 青蒿琥酯 | 88495-63-0 | 173925 |
| WZ-3146, 98%, a mutant selective EGFR inhibitor WZ 3146 | 1214265-56-1 | 1417793 |
| Dacomitinib, 98%, a potent irreversible ErbB inbibitor 达克替尼 | 1110813-31-4 | 1525219 |
| Icotinib, 98%, a potent EGFR inhibitor 埃克替尼 | 610798-31-7 | 1568587 |
| Afatinib dimaleate, 99%, an irreversible EGFR family inhibitor 阿法替尼双马来酸盐 | 850140-73-7 | 1648192 |
| GLPG0634 analog, 98%, a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3 GLPG0634 analog | 1206101-20-3 | 1684518 |
| Osimertinib, 98%, a potent and selective mutated forms EGFR inhibitor 迈瑞替尼 | 1421373-65-0 | 1761088 |
| NSC 42834, 95%, a novel specific inhibitor of JAK2 NSC 42834 | 195371-52-9 | 1811722 |
| CX-6258, 99%, a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor CX-6258 | 1202916-90-2 | 1868028 |
| Lcotinib hydrochloride, 99%, a potent and specific EGFR inhibitor with an IC50 of 5 nM 盐酸埃克替尼 | 1204313-51-8 | 1891191 |
| FLLL32, 98%, a STAT3 inhibitor derived from the natural product curcumin FLLL32 | 1226895-15-3 | 2059891 |
| Allitinib tosylate, 98%, a novel irreversible inhibitor of EGFR and ErbB2 Allitinib tosylate | 1050500-29-2 | 2275899 |
蛋白免疫印迹（WB）
| 品名 | CAS | 货号 |
|---|---|---|
| Bovine serum albumin, 98%, Australia origin, low IgG, low fatty acid 牛血清白蛋白 | 9048-46-8 | 109636 |
| Acrylamide, 99% 丙烯酰胺 | 79-06-1 | 166974 危化品 |
| Super ECL Plus Detection Reagent (component A), used with 1912570 Super ECL Plus超敏发光液(A液) | / | 946079 |
| Super ECL Plus Detection Reagent (component B), used with 946079 Super ECL Plus超敏发光液(B液) | / | 1912570 |
| Sodium dodecyl sulfate, 99%, for biochemistry 十二烷基硫酸钠 | 151-21-3 | 105893促 |
核心生化试剂
| 品名 | CAS | 货号 |
|---|---|---|
| Premium Fetal Bovine Serum 精制胎牛血清 | / | 9410422 |
| 4-Nonylphenyl-polyethylene glycol 4-壬基苯基-聚乙二醇 | 9016-45-9 | 931454 危化品 |
| 2-Mercaptoethanol, 99%, for electrophoresis and molecular biology 2-巯基乙醇 | 60-24-2 | 249096促 危化品 |
| D-(+)-Glucose, 99%, for bio D-(+)-葡萄糖 | 50-99-7 | 936778促 |
| Proteinase K, for bio, 30-40U/mg 蛋白酶 K | 39450-01-6 | 968706 |
| Acrylamide, 99% 丙烯酰胺 | 79-06-1 | 166974 危化品 |
| Sodium dodecyl sulfate, 99%, for electrophoresis 十二烷基硫酸钠 | 151-21-3 | 160975促 |
相关耗材
| 品名 | CAS | 货号 |
|---|---|---|
| Single-channel mechanical pipettor, Volume range: 100 - 1000 μL, Increment: 5.0 μL 单道手动可调移液器 | / | 1122427 |
| Pipette tips, 1000 μL, blue, 1000 tips/pack 移液器吸头 | / | 672890 |
| 96-well UV-transparent microplate, Non-sterile, bagged, black without lid, 5 tips/bag, 10 bags/case 96孔紫外可透微孔板 | / | 9478529 |
| 96-well non-removable high-binding ELISA plate, Bagged, transparent without lid, 5 tips/bag, 20 bags/case 96孔不可拆高结合力酶标板 | / | 9478546 |
| Pipette tips, 10 μL, clear, low Retention, 1000 tips/pack 移液器吸头 | / | 1438538 |
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