百灵威电离/阳离子脂质领域新品
2023-05-24 · 推荐产品 · 百灵威授权转载
Ionizable lipids play a key role in the formulation of Lipid Nanoparticles (LNPs) used to deliver RNA therapeutics.
We have added three new products to our Ionizable and Cationic Lipid product suite.
- Lipid C24
Lipid C24 is an ionizable lipid used in lipid nanoparticle formulations for delivery of RNA. Key features:
• High binding and pseudoneutralizing antibodies
• Minimal injection site inflammation
- 93-O17S
93-O17S is a lipidoid used for generating lipid nanoparticles to deliver RNA, peptides, and nucleotides. Key features:
• Delivers Cre recombinase mRNA in mice
• Genome editing capabilities
• cGAMP delivery with potential as an in situ cancer vaccine
- YSK05
YSK05 is an ionizable lipid used to make lipid nanoparticles for delivery of siRNA. YSK05 LNPs delivered siRNA to hepatocytes and demonstrated gene silencing after intravenous administration.
- Echelon's Ionizable Lipids are are sold as Research Use Only (RUO).
The COVID-19 pandemic has pushed ionizable lipids into the limelight with the rapid development of mRNA-based vaccines. A key part of this technology are the lipid nanoparticles (LNPs) used to deliver RNA.
mRNA-based vaccines are the culmination of two decades of research, and their incorporation of LNPs is a key factor in their success. There are countless applications for additional vaccines and therapeutics in the future.
