神经信号通路相关高活性小分子抑制剂、激动剂、拮抗剂
2020-04-22 · 系列介绍 · 百灵威授权转载
G蛋白偶联受体（GPCRs）包括5-HT受体、组胺受体等，是神经信号通路中重要的治疗靶点（图1）[1-2]；Notch信号，如β-和γ-分泌酶，在调节神经干细胞的增殖、分化中有着极其重要的作用。
GPCRs和Notch信号等神经信号，与中风、阿尔茨海默症等神经系统疾病发生密切相关。
百灵威提供神经信号通路中的小分子抑制剂、激动剂、拮抗剂，可作用于5-HT受体、γ-分泌酶等多个靶点：
- 靶点清晰明确，便于选择；
- >80%的产品纯度高于98%；
- 生物活性经多客户验证；
- 性价比高：同比每个产品可节约5%-20%成本。
![图1 GPCR信号的细胞内部环境<sup>[1]</sup>](/assets/jk-articles-all/0a576a921ece21c6d0fd85ad.png)
图1 GPCR信号的细胞内部环境[1]
| 品名 | 产品描述 | 货号&CAS |
|---|---|---|
| Acemetacin, 98% 阿西美辛 | a COX inhibitor | 612781 53164-05-9 |
| Agomelatine, 99% 阿戈美拉汀 | a competitive antagonist of (5-HT2C) receptors | 621992 138112-76-2 |
| Amisulpride, 98% 阿米舒必利 | a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively | 375990 71675-85-9 |
| Atomoxetine hydrochloride, 99% 盐酸托莫西汀 | a selective norepinephrine reuptake inhibitor | 506507 82248-59-7 |
| Cyproheptadine hydrochloride sesquihydrate, 99% 赛庚啶盐酸盐倍半水合物 | an antihistamine and is an antagonist of serotonin and histamine2 | 259064 41354-29-4 |
| Dapoxetine hydrochloride, 98% 盐酸达泊西汀 | a short-acting novel selective serotonin reuptake inhibitor | 105394 129938-20-1 |
| DAPT, 98% DAPT | a γ-secretase inhibitor | 286160 208255-80-5 |
| Escitalopram oxalate, 98% 草酸右旋西酞普兰 | a selective serotonin reuptake inhibitor | 317177 219861-08-2 |
| Etoricoxib, 98% 依托考昔 | a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood | 259023 202409-33-4 |
| Granisetron hydrochloride, 98% 盐酸格拉司琼 | a serotonin 5-HT3 receptor antagonist | 384285 107007-99-8 |
| Ivabradine hydrochloride, 98% 盐酸伊伐布雷定 | a If inhibitor | 813721 148849-67-6 |
| Levosulpiride, 98% 左旋舒必利 | a selective antagonist for D2 dopamine receptor | 519766 23672-07-3 |
| Medetomidine hydrochloride, 99% 盐酸美托嘧啶 | an agonist of adrenergic alpha-2 receptor | 832160 86347-15-1 |
| Methyldopa sesquihydrate, 98% 甲基多巴半水合物 | an alpha-adrenergic agonist | 329925 555-30-6 |
| Naftopidil, 98% 萘哌地尔 | a selective α1-adrenergic receptor antagonist | 434183 57149-07-2 |
| Nefiracetam, 99% 奈非西坦 | a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions | 512359 77191-36-72 |
| Noopept, 99% N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 | a medication promoted and prescribed in Russia and neighbouring countries as a nootropic | 1238183 157115-85-0 |
| Olopatadine hydrochloride, 99% 盐酸奥洛他定 | a selective H1 receptor antagonist | 156717 140462-76-6 |
| Phentolamine methanesulfonate salt, 98% 甲磺酸酚妥拉明 | a nonselective alpha-adrenergic antagonist | 300598 65-28-1 |
| Prucalopride succinate, 99% 琥珀酸普卡必利 | a selective high affinity 5-HT4 receptor agonist | 1239118 179474-85-2 |
| Ropinirole HCl, 99% 罗匹尼罗盐酸盐 | a selective dopamine D2 receptor inhibitor with IC50 of 29 nM | 102850 91374-20-8 |
| Roxatidine acetate hydrochloride, 98% 盐酸罗沙替丁醋酸酯 | a specific and competitive histamin H2 receptor antagonist | 201789 93793-83-0 |
| Venlafaxine hydrochloride, 98% 盐酸文拉法辛 | an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI) | 146177 99300-78-4 |
| Vilazodone hydrochloride, 98% 盐酸维拉佐酮 | a 5-HT1A receptor partial agonist | 1559446 163521-08-2 |
| Xylometazoline hydrochloride, 98% 盐酸赛洛唑啉 | an α-adrenoceptor agonist | 304079 1218-35-5 |
| Zolmitriptan, 98% 佐米曲普坦 | a selective 5-HT1B/1D/1F receptor agonist | 377186 139264-17-8 |
点击查看更多产品（按靶点分类）
100442
145202-66-0
Rizatriptan benzoate, 99%
产品描述:
an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks
an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks
1020866
177834-92-3
Eletriptan hydrobromide, 99%
产品描述:
a selective 5-HT1B/1D receptor agonist
a selective 5-HT1B/1D receptor agonist
1238240
846589-98-8
Lorcaserin hydrochloride, 98%
产品描述:
a selective full agonist of human 5-HT2C receptor
a selective full agonist of human 5-HT2C receptor
1239118
179474-85-2
Prucalopride succinate, 99%
产品描述:
a selective high affinity 5-HT4 receptor agonist
a selective high affinity 5-HT4 receptor agonist
1239146
85650-56-2
Asenapine maleate, 98%
产品描述:
a 5-HT receptor antagonist
a 5-HT receptor antagonist
144809
103628-48-4
Sumatriptan succinate, 98%
产品描述:
a 5-HT1 receptor agonist
a 5-HT1 receptor agonist
157728
153-98-0
Serotonin hydrochloride, 98%
产品描述:
a monoamine neurotransmitter and endogenous 5-HT receptor agonist
a monoamine neurotransmitter and endogenous 5-HT receptor agonist
1750573
706782-28-7
Pimavanserin tartrate, 99%
产品描述:
a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively
a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively
242568
135729-62-3
Palonosetron hydrochloride, 100%
产品描述:
a 5-HT3 antagonist
a 5-HT3 antagonist
242605
129722-12-9
Aripiprazole, 98%
产品描述:
a human 5-HT1A receptor partial agonist
a human 5-HT1A receptor partial agonist
259064
41354-29-4
Cyproheptadine hydrochloride sesquihydrate, 99%
产品描述:
an antihistamine and is an antagonist of serotonin and histamine2
an antihistamine and is an antagonist of serotonin and histamine2
296982
549-18-8
Amitriptyline hydrochloride, 98%
产品描述:
a dibenzocycloheptene-derivative tricyclic antidepressant (TCA)
a dibenzocycloheptene-derivative tricyclic antidepressant (TCA)
303244
27833-64-3
Lidocaine succinate, 98%
产品描述:
a 5-HT inhibitor; dopamine receptor
a 5-HT inhibitor; dopamine receptor
377186
139264-17-8
Zolmitriptan, 98%
产品描述:
a selective 5-HT1B/1D/1F receptor agonist
a selective 5-HT1B/1D/1F receptor agonist
384285
107007-99-8
Granisetron hydrochloride, 98%
产品描述:
a serotonin 5-HT3 receptor antagonist
a serotonin 5-HT3 receptor antagonist
412405
99614-02-5
Ondansetron, 98%
产品描述:
a serotonin 5-HT3 receptor antagonist
a serotonin 5-HT3 receptor antagonist
513162
181183-52-8
Almotriptan malate, 98%
产品描述:
a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults
a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults
522188
105826-92-4
Tropisetron monohydrochloride, 99%
产品描述:
a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist
a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist
574335
85650-52-8
Mirtazapine, 98%
产品描述:
5-HT Receptor
5-HT Receptor
612932
69-09-0
Chlorpromazine hydrochloride, 98%
产品描述:
dopamine receptor and potassium channel inhibitor
dopamine receptor and potassium channel inhibitor
621992
138112-76-2
Agomelatine, 99%
产品描述:
a competitive antagonist of (5-HT2C) receptors
a competitive antagonist of (5-HT2C) receptors
102648
53716-49-7
Carprofen, 98%
产品描述:
a COX2 inhibitor
a COX2 inhibitor
154153
22494-42-4
Diflunisal, 98%
产品描述:
a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients
a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients
179536
62-44-2
4'-Ethoxyacetanilide, 99%
产品描述:
a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity
a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity
193542
69-72-7
Salicylic acid, 99%
产品描述:
inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation
inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation
217197
71125-38-7
Meloxicam, 99%
产品描述:
a selective COX inhibitor
a selective COX inhibitor
249233
41340-25-4
Etodolac, 98%
产品描述:
a COX inhibitor
a COX inhibitor
259023
202409-33-4
Etoricoxib, 98%
产品描述:
a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood
a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood
260643
70374-39-9
Lornoxicam, 98%
产品描述:
a non-steroidal COX-1/COX-2 inhibitor
a non-steroidal COX-1/COX-2 inhibitor
408218
15687-27-1
Ibuprofen, 98%
产品描述:
an anti-inflammatory inhibitor targeting COX-1 and COX-2
an anti-inflammatory inhibitor targeting COX-1 and COX-2
433895
38194-50-2
Sulindac, 98%
产品描述:
a COX inhibitor
a COX inhibitor
458307
36322-90-4
Piroxicam, 98%
产品描述:
a non-selective COX inhibitor
a non-selective COX inhibitor
474412
53-86-1
Indomethacin, 98%
产品描述:
a nonselective COX1 and COX2 inhibitor
a nonselective COX1 and COX2 inhibitor
492148
181695-72-7
Valdecoxib, 98%
产品描述:
a COX-2 selective inhibitor
a COX-2 selective inhibitor
552207
2438-72-4
Bufexamac, 98%
产品描述:
a COX inhibitor
a COX inhibitor
585483
61-68-7
Mefenamic acid, 98%
产品描述:
a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively
a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively
588527
15307-79-6
Diclofenac sodium, 98%
产品描述:
a non-selective COX inhibitor
a non-selective COX inhibitor
612781
53164-05-9
Acemetacin, 98%
产品描述:
COX inhibitor
COX inhibitor
920591
78281-72-8
Nepafenac, 99%
产品描述:
a selective COX-2 inhibitor
a selective COX-2 inhibitor
922677
22071-15-4
Ketoprofen, 98%
产品描述:
a COX1/2 inhibitor
a COX1/2 inhibitor
1238183
157115-85-0
Noopept, 99%
产品描述:
a medication promoted and prescribed in Russia and neighbouring countries as a nootropic
a medication promoted and prescribed in Russia and neighbouring countries as a nootropic
421062
6384-92-5
N-Methyl-D-aspartic acid, 98%
产品描述:
a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor
a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor
914947
41100-52-1
Memantine hydrochloride, 99%
产品描述:
amantadine derivative
amantadine derivative
1014977
104075-48-1
Atipamezole hydrochloride, 98%
产品描述:
a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM
a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM
1213437
104054-27-5
Atipamezole, 98%
产品描述:
a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM
a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM
126556
19237-84-4
Prazosin hydrochloride, 98%
产品描述:
an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety
an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety
1362104
145108-58-3
Dexmedetomidine hydrochloride, 99%
产品描述:
an agonist of adrenergic alpha-2 receptor
an agonist of adrenergic alpha-2 receptor
192714
63-92-3
Phenoxybenzamine hydrochloride, 98%
产品描述:
a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma
a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma
222111
5985-28-4
Synephrine HCl, 98%
产品描述:
an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids
an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids
279472
81403-68-1
Alfuzosin hydrochloride, 99%
产品描述:
an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH)
an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH)
283519
522-48-5
Tetrahydrozoline hydrochloride, 98%
产品描述:
a α-adrenoceptor agonist
a α-adrenoceptor agonist
300598
65-28-1
Phentolamine methanesulfonate salt, 98%
产品描述:
a nonselective alpha-adrenergic antagonist
a nonselective alpha-adrenergic antagonist
304079
1218-35-5
Xylometazoline hydrochloride, 98%
产品描述:
an α-adrenoceptor agonist
an α-adrenoceptor agonist
329925
555-30-6
Methyldopa sesquihydrate, 98%
产品描述:
an alpha-adrenergic agonist
an alpha-adrenergic agonist
340964
77883-43-3
Doxazosin mesylate, 98%
产品描述:
a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors
a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors
434183
57149-07-2
Naftopidil, 98%
产品描述:
a selective α1-adrenergic receptor antagonist
a selective α1-adrenergic receptor antagonist
506932
550-99-2
Naphazoline hydrochloride, 99%
产品描述:
an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine
an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine
529033
4205-91-8
Clonidine hydrochloride, 98%
产品描述:
an agonist of α2-adrenoceptor and potent antihypertensive agent
an agonist of α2-adrenoceptor and potent antihypertensive agent
547327
29110-48-3
Guanfacine hydrochloride, 98%
产品描述:
an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors
an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors
592193
23076-35-9
Xylazine hydrochloride, 98%
产品描述:
a strong α2-adrenergic agonist ,Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine
a strong α2-adrenergic agonist ,Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine
708766
90038-01-0
Detomidine hydrochloride, 99%
产品描述:
an imidazole derivative and α2-adrenergic agonist
an imidazole derivative and α2-adrenergic agonist
770912
152520-56-4
Nebivolol hydrochloride, 98%
产品描述:
a selective β1 antagonist
a selective β1 antagonist
813721
148849-67-6
Ivabradine hydrochloride, 98%
产品描述:
a If inhibitor
a If inhibitor
832160
86347-15-1
Medetomidine hydrochloride, 99%
产品描述:
an agonist of adrenergic alpha-2 receptor
an agonist of adrenergic alpha-2 receptor
900071
498-45-3
Scopine, 97%
产品描述:
the metabolite of anisodine, which is a α1-adrenergic receptor agonist
the metabolite of anisodine, which is a α1-adrenergic receptor agonist
976415
160970-54-7
Silodosin, 98%
产品描述:
an α1-adrenoceptor antagonist
an α1-adrenoceptor antagonist
163255
114-80-7
Neostigmine bromide, 98%
产品描述:
a reversible acetylcholinesterase inhibitor
a reversible acetylcholinesterase inhibitor
257795
119302-91-9
Rocuronium bromide, 98%
产品描述:
an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia
an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia
285174
3717-88-2
Flavoxate hydrochloride, 99%
产品描述:
a muscarinic AChR antagonist
a muscarinic AChR antagonist
358978
596-51-0
Glycopyrrolate, 98%
产品描述:
a muscarinic competitive antagonist used as an antispasmodic
a muscarinic competitive antagonist used as an antispasmodic
408413
1508-75-4
Tropicamide, 99%
产品描述:
a potent selective M4 antagonist
a potent selective M4 antagonist
553649
52-49-3
Trihexyphenidyl hydrochloride, 98%
产品描述:
an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor
an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor
597495
10405-02-4
Trospium chloride, 98%
产品描述:
a competitive muscarinic cholinergic receptor antagonist
a competitive muscarinic cholinergic receptor antagonist
622204
242478-38-2
Solifenacin succinate, 98%
产品描述:
a muscarinic receptor antagonist
a muscarinic receptor antagonist
912635
133099-07-7
Darifenacin hydrobromide, 98%
产品描述:
a selective M3 muscarinic receptor antagonist with pKi of 8.9
a selective M3 muscarinic receptor antagonist with pKi of 8.9
1188281
190786-44-8
Bepotastine besylate, 98%
产品描述:
a histamine H1 receptor anatagonist
a histamine H1 receptor anatagonist
153710
113-92-8
Chlorpheniramine maleate, 99%
产品描述:
a histamine H1 receptor antagonist
a histamine H1 receptor antagonist
156717
140462-76-6
Olopatadine hydrochloride, 99%
产品描述:
a selective H1 receptor antagonist
a selective H1 receptor antagonist
164375
108612-45-9
Mizolastine, 98%
产品描述:
a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions
a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions
173155
129-74-8
Buclizine HCl, 98%
产品描述:
an antihistamine and anticholinergic of the piperazine derivative family
an antihistamine and anticholinergic of the piperazine derivative family
200704
66357-59-3
Ranitidine hydrochloride, 98%
产品描述:
a histamine H2-receptor antagonist that inhibits stomach acid production
a histamine H2-receptor antagonist that inhibits stomach acid production
201789
93793-83-0
Roxatidine acetate hydrochloride, 98%
产品描述:
a specific and competitive histamin H2 receptor antagonist.
a specific and competitive histamin H2 receptor antagonist.
266846
51481-61-9
Cimetidine, 99%
产品描述:
a histamine-2 (H2) receptor antagonist
a histamine-2 (H2) receptor antagonist
277872
56-92-8
Histamine dihydrochloride, 98%
产品描述:
a histamine receptor agonist
a histamine receptor agonist
291761
76824-35-6
Famotidine, 99%
产品描述:
Histamine H2 receptor antagonist
Histamine H2 receptor antagonist
301890
79307-93-0
Azelastine hydrochloride, 98%
产品描述:
a potent, second-generation, selective, histamine antagonist
a potent, second-generation, selective, histamine antagonist
302490
147-24-0
Diphenhydramine hydrochloride, 99%
产品描述:
a histamine H1 antagonist
a histamine H1 antagonist
302672
153439-40-8
Fexofenadine hydrochloride, 98%
产品描述:
a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years)
a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years)
314310
83881-52-1
Cetirizine dihydrochloride, 99%
产品描述:
a selective histamine H1 receptor antagonist
a selective histamine H1 receptor antagonist
338442
79794-75-5
Loratadine, 98%
产品描述:
a highly potent selective H1 receptor antagonist
a highly potent selective H1 receptor antagonist
372427
58-33-3
Promethazine hydrochloride, 98%
产品描述:
a potent histamine H1 receptor antagonist
a potent histamine H1 receptor antagonist
382196
51-74-1
Histamine diphosphate hydrate, 98%
产品描述:
a histamine H1/H2 receptor agonist
a histamine H1/H2 receptor agonist
441841
1104-22-9
Meclizine dihydrochloride, 99%
产品描述:
a histamine H1 receptor antagonist used to treat nausea and motion sickness
a histamine H1 receptor antagonist used to treat nausea and motion sickness
459378
14976-57-9
Clemastine fumarate, 98%
产品描述:
a selective histamine H1 receptor antagonist with IC50 of 3 nM
a selective histamine H1 receptor antagonist with IC50 of 3 nM
512758
562-10-7
Doxylamine succinate, 98%
产品描述:
a first generation antihistamine
a first generation antihistamine
573206
100643-71-8
Desloratadine, 98%
产品描述:
a potent antagonist for human histamine H1 receptor
a potent antagonist for human histamine H1 receptor
574461
34580-14-8
Ketotifen fumarate salt, 99%
产品描述:
a second-generation noncompetitive H1-antihistamine and mast cell stabilizer
a second-generation noncompetitive H1-antihistamine and mast cell stabilizer
904270
100299-08-9
Pemirolast potassium, 98%
产品描述:
a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent
a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent
924014
137-58-6
Lidocaine, 99%
产品描述:
a commonly used local anesthetics of amide derivative, a drug to treat ventricular arrhythmia and an effective tumor-inhibitor
a commonly used local anesthetics of amide derivative, a drug to treat ventricular arrhythmia and an effective tumor-inhibitor
102850
91374-20-8
Ropinirole HCl, 99%
产品描述:
a selective dopamine D2 receptor inhibitor with IC50 of 29 nM
a selective dopamine D2 receptor inhibitor with IC50 of 29 nM
115511
59-92-7
Levodopa, 99%
产品描述:
a natural form of DOPA
a natural form of DOPA
140636
106266-06-2
Risperidone, 100%
产品描述:
Dopamine, serotonin, adrenergic and histamine receptors antagonist
Dopamine, serotonin, adrenergic and histamine receptors antagonist
143208
23007-85-4
MPTP hydrochloride, 98%
产品描述:
a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease
a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease
186095
138982-67-9
Ziprasidone hydrochloride monohydrate, 99%
产品描述:
a novel and potent dopamine and serotonin (5-HT) receptor antagonist
a novel and potent dopamine and serotonin (5-HT) receptor antagonist
216475
191217-81-9
Pramipexole dihydrochloride monohydrate, 99%
产品描述:
a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease
a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease
260381
57808-66-9
Domperidone, 98%
产品描述:
dopamine blocker and an antidopaminergic reagent
dopamine blocker and an antidopaminergic reagent
321078
111974-72-2
Quetiapine hemifumarate salt, 98%
产品描述:
an inhibitor of D2DR and SR-2A
an inhibitor of D2DR and SR-2A
375990
71675-85-9
Amisulpride, 98%
产品描述:
a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively
a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively
407698
665-66-7
1-Adamantanamine hydrochloride, 99%
产品描述:
antiviral and antiparkinsonian compound
antiviral and antiparkinsonian compound
496697
132539-06-1
Olanzapine, 99%
产品描述:
a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist
a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist
519766
23672-07-3
Levosulpiride, 98%
产品描述:
a selective antagonist for D2 dopamine receptor
a selective antagonist for D2 dopamine receptor
563266
66104-23-2
Pergolide mesylate salt, 98%
产品描述:
an antiparkinsonian agent which functions as a dopaminergic agonist
an antiparkinsonian agent which functions as a dopaminergic agonist
566212
133454-47-4
Iloperidone, 99%
产品描述:
a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms
a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms
791040
483-14-7
Rotundine, 98%
产品描述:
an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively
an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively
967391
132810-10-7
Blonanserin, 100%
产品描述:
a D2/5-HT2 receptor antagonist
a D2/5-HT2 receptor antagonist
977215
144598-75-4
Paliperidone, 99%
产品描述:
a potent D2 and 5-HT2A antagonist
a potent D2 and 5-HT2A antagonist
367035
39133-31-8
Trimebutine, 99%
产品描述:
a drug with antimuscarinic and weak mu opioid agonist effects
a drug with antimuscarinic and weak mu opioid agonist effects
503199
357-08-4
Naloxone hydrochloride, 98%
产品描述:
an opioid inverse agonist drug used to counter the effects of opiate overdose.
an opioid inverse agonist drug used to counter the effects of opiate overdose.
988688
34552-83-5
Loperamide hydrochloride, 98%
产品描述:
an opioid-receptor agonist
an opioid-receptor agonist
116850
33125-97-2
Etomidate, 99%
产品描述:
a GABAA receptors agonist
a GABAA receptors agonist
163651
485-49-4
(+)-Bicuculline, 99%
产品描述:
a GABAA antagonist
a GABAA antagonist
180751
145821-59-6
Tiagabine hydrochloride, 99%
产品描述:
a potent and selective GABA reuptake inhibitor
a potent and selective GABA reuptake inhibitor
462722
69308-37-8
(R)-Baclofen, 98%
产品描述:
a selective GABAB receptor agonist
a selective GABAB receptor agonist
512359
77191-36-7
Nefiracetam, 99%
产品描述:
a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions
a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions
946916
1744-22-5
Riluzole, 98%
产品描述:
a glutamate antagonist
a glutamate antagonist
970349
78755-81-4
Flumazenil, 100%
产品描述:
a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses
a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses
258111
120011-70-3
Donepezil hydrochloride, 99%
产品描述:
a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine
a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine
373981
122892-31-3
Itopride hydrochloride, 99%
产品描述:
an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor
an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor
396829
123441-03-2
Rivastigmine tartrate, 99%
产品描述:
an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase
an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase
622196
129101-54-8
Rivastigmine tartrate, 98%
产品描述:
acetylcholinesterase and butyrylcholinesterase inhibitor
acetylcholinesterase and butyrylcholinesterase inhibitor
105394
129938-20-1
Dapoxetine hydrochloride, 98%
产品描述:
a short-acting novel selective serotonin reuptake inhibitor
a short-acting novel selective serotonin reuptake inhibitor
146177
99300-78-4
Venlafaxine hydrochloride, 98%
产品描述:
an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI)
an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI)
1559446
163521-08-2
Vilazodone hydrochloride, 98%
产品描述:
a 5-HT1A receptor partial agonist
a 5-HT1A receptor partial agonist
1807493
960203-27-4
Vortioxetine hydrobromide, 99%
产品描述:
a 5-HT receptor inhibitor
a 5-HT receptor inhibitor
200317
78246-49-8
Paroxetine hydrochloride, 99%
产品描述:
a selective serotonin-reuptake inhibitor
a selective serotonin-reuptake inhibitor
317177
219861-08-2
Escitalopram oxalate, 98%
产品描述:
a selective serotonin reuptake inhibitor
a selective serotonin reuptake inhibitor
357465
56296-78-7
Fluoxetine hydrochloride, 98%
产品描述:
an antidepressant and a selective serotonin reuptake inhibitor
an antidepressant and a selective serotonin reuptake inhibitor
360854
61718-82-9
Fluvoxamine maleate, 98%
产品描述:
a selective serotonin (5-HT) reuptake inhibitor (SSRI)
a selective serotonin (5-HT) reuptake inhibitor (SSRI)
365552
136434-34-9
Duloxetine hydrochloride, 99%
产品描述:
a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM
a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM
618179
93413-62-8
O-Desmethylvenlafaxine, 98%
产品描述:
a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor
a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor
949909
79559-97-0
Sertraline hydrochloride, 98%
产品描述:
an antidepressant of the selective serotonin reuptake inhibitor (SSRI)
an antidepressant of the selective serotonin reuptake inhibitor (SSRI)
237425
107-97-1
Sarcosine, 99%
产品描述:
a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site
a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site
