细胞周期/DNA损伤相关高活性小分子抑制剂
2020-04-22 · 系列介绍 · 百灵威授权转载
细胞周期包括DNA合成（S期）和有丝分裂（M期）两个阶段，S期和M期被间隔期G1期和G2期分隔（图1）。细胞周期可以被细胞内外的各种信号所调控，为确保周期内每一时相事件有序完成并与外界环境因素相联系，需要细胞周期检查点的调控，在此期间可以监测细胞生长和DNA完整性的蛋白质是必不可少的。异常的细胞分裂或受损 DNA 的传播会导致肿瘤的发生。
环境中物理或化学的污染因素均会引起机体内细胞DNA结构的改变，即DNA损伤，如果未能及时进行DNA损伤修复，就可能发生细胞衰老、细胞凋亡和细胞癌变。
百灵威提供细胞周期/DNA损伤信号通路中的小分子抑制剂，可作用于CDK、PLK、HDAC等多个肿瘤研究靶点：
- 靶点清晰明确，便于选择；
- >80%的产品纯度高于98%；
- 生物活性经多客户验证；
- 90%以上有现货；
- 性价比高：同比每个产品可节约5%-20%成本。
![图1 真核细胞细胞周期示意图 <sup>[1]</sup>](/assets/jk-articles-all/704dbeb32aefc8270e463fc8.png)
图1 真核细胞细胞周期示意图 [1]
产品列表（按靶点分类）
618339
667463-62-9
GSK 3 Inhibitor IX, 99%
Description:
a potent, selective, reversible and ATP-competitive inhibitor
a potent, selective, reversible and ATP-competitive inhibitor
2286674
199986-75-9
CVT-313, 98%
Description:
a potent, selective, reversible, and ATP-competitive inhibitor of CDK2
a potent, selective, reversible, and ATP-competitive inhibitor of CDK2
555545
142273-20-9
Kenpaullone, 98%
Description:
a potent inhibitor of CDK1/cyclin B and GSK-3β
a potent inhibitor of CDK1/cyclin B and GSK-3β
144505
161058-83-9
NU2058, 99%
Description:
a guanine-based CDK inhibitor
a guanine-based CDK inhibitor
338303
212844-53-6
Purvalanol A, 98%
Description:
a potent CDK inhibitor
a potent CDK inhibitor
100441
212844-54-7
Purvalanol B, 97%
Description:
a cyclin-dependent kinase inhibitor
a cyclin-dependent kinase inhibitor
2062938
872573-93-8
Ro-3306, 96%
Description:
a potent and selective inhibitor of CDK1
a potent and selective inhibitor of CDK1
1004546
345627-80-7
SNS-032, 99%
Description:
a selective CDK2 inhibitor
a selective CDK2 inhibitor
1232528
443797-96-4
JNJ-7706621, 98%
Description:
a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2
a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2
804158
722544-51-6
Barasertib-HQPA, 98%
Description:
a highly selective Aurora B inhibitor
a highly selective Aurora B inhibitor
1563114
422513-13-1
Hesperadin, 98%
Description:
an ATP-competitive inhibitor of aurora B kinase
an ATP-competitive inhibitor of aurora B kinase
583852
656820-32-5
Reversine, 98%
Description:
a novel class of ATP-competitive Aurora kinase inhibitor
a novel class of ATP-competitive Aurora kinase inhibitor
1750763
1228591-30-7
TAK-632, 98%
Description:
a potent pan-RAF inhibitor
a potent pan-RAF inhibitor
1415853
398493-79-3
PHA-680632, 98%
Description:
an aurora kinase inhibitor
an aurora kinase inhibitor
624601
516480-79-8
BML-277, 97%
Description:
a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM
a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM
790544
155558-32-0
Hydroxyfasudil hydrochloride, 98%
Description:
a ROCK inhibitor
a ROCK inhibitor
1018947
1226056-71-8
Thiazovivin, 98%
Description:
a potent ROCK inhibitor, which can protect human embryonic stem cells
a potent ROCK inhibitor, which can protect human embryonic stem cells
262595
146986-50-7
Y-27632, 99%
Description:
an ATP-competitive inhibitor of ROCK-I and ROCK-II
an ATP-competitive inhibitor of ROCK-I and ROCK-II
101990
105628-07-7
Fasudil hydrochloride, 98%
Description:
a nonspecific ROCK inhibitor , with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively
a nonspecific ROCK inhibitor , with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively
1417791
129830-38-2
Y-27632 dihydrochloride, 99%
Description:
a selective ROCK1 (p160ROCK) inhibitor
a selective ROCK1 (p160ROCK) inhibitor
9016864
1342278-01-6
RKI-1447, 98%
Description:
a potent small molecule inhibitor of ROCK1 and ROCK2
a potent small molecule inhibitor of ROCK1 and ROCK2
165146
1784-03-8
TAME hydrochloride, 99%
Description:
an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest
an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest
190614
446-86-6
Azathioprine, 98%
Description:
a drug that suppresses the immune system and is used in organ transplantation and autoimmune disease
a drug that suppresses the immune system and is used in organ transplantation and autoimmune disease
2062986
910462-43-0
Domatinostat, 98%
Description:
a selective class I HDAC inhibitor
a selective class I HDAC inhibitor
2275937
1375465-91-0
ACY-738, 99%
Description:
a potent, selective and orally-bioavailable HDAC6 inhibitor
a potent, selective and orally-bioavailable HDAC6 inhibitor
1834845
1314890-29-3
TMP269, 98%
Description:
a novel and selective class Iia histone deacetylase (HDAC) inhibitor
a novel and selective class Iia histone deacetylase (HDAC) inhibitor
1831353
1440209-96-0
BRD73954, 98%
Description:
a potent and selective HDAC inhibitor
a potent and selective HDAC inhibitor
1833694
1418033-25-6
LMK-235, 99%
Description:
a potent and selective HDAC4/5 inhibitor
a potent and selective HDAC4/5 inhibitor
1833307
1429651-50-2
HPOB, 95%
Description:
a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6)
a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6)
1891183
1252003-15-8
Tubastatin-A, 98%
Description:
a potent and selective HDAC6 inhibitor
a potent and selective HDAC6 inhibitor
2286551
1477949-42-0
Santacruzamate A, 98%
Description:
a potent and selective HDAC2 inhibitor
a potent and selective HDAC2 inhibitor
926452
251456-60-7
M344, 98%
Description:
an inhibitor of histone deacetylase (IC50=100 nM)
an inhibitor of histone deacetylase (IC50=100 nM)
2286670
937039-45-7
Pimelic Diphenylamide 106, 98%
Description:
a slow, tight-binding inhibitor
a slow, tight-binding inhibitor
786110
848354-66-5
PTACH, 98%
Description:
a SAHA-based novel inhibitor of human HDAC
a SAHA-based novel inhibitor of human HDAC
1811748
1357389-11-7
RGFP966, 98%
Description:
a highly selective HDAC3 inhibitor
a highly selective HDAC3 inhibitor
836786
537034-15-4
NKL 22, 98%
Description:
a HDAC inhibitor
a HDAC inhibitor
1834137
1403783-31-2
Nexturastat A, 98%
Description:
a potent and selective HDAC6 inhibitor
a potent and selective HDAC6 inhibitor
2286671
537672-41-6
UF010, 98%
Description:
a potent and selective HADC inhibitor
a potent and selective HADC inhibitor
447634
287383-59-9
Scriptaid, 98%
Description:
a potent histone deacetylase (HDAC) inhibitor, used in cancer research
a potent histone deacetylase (HDAC) inhibitor, used in cancer research
1004535
128517-07-7
Romidepsin, 98%
Description:
a potent HDAC1 and HDAC2 inhibitor
a potent HDAC1 and HDAC2 inhibitor
1564431
1310693-92-5
Tubastatin A HCl, 98%
Description:
a potent and selective HDAC6 inhibitor
a potent and selective HDAC6 inhibitor
1831227
926259-99-6
BG45, 98%
Description:
a HDAC class I inhibitor with selectivity for HDAC3
a HDAC class I inhibitor with selectivity for HDAC3
245478
1716-12-7
Sodium phenylbutyrate, 98%
Description:
a histone deacetylase inhibitor
a histone deacetylase inhibitor
1759204
1080622-86-1
CP-466722, 98%
Description:
a rapidly reversible inhibitor of ATM
a rapidly reversible inhibitor of ATM
1684910
1345675-02-6
ETP46464, 99%
Description:
an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 Nm respectively.
an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 Nm respectively.
1564473
1232410-49-9
VE-821, 99%
Description:
a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
1564012
905973-89-9
CGK733, 98%
Description:
a potent ATM/ATR inhibitor
a potent ATM/ATR inhibitor
1239105
925701-49-1
KU-60019, 98%
Description:
an improved KU-55933 analog
an improved KU-55933 analog
2276005
1380672-07-0
G007-LK, 99%
Description:
a potent and selective inhibitor of TNKS1 and TNKS2
a potent and selective inhibitor of TNKS1 and TNKS2
1018722
459868-92-9
Rucaparib phosphate, 98%
Description:
a potent and oral PARP inhibitor
a potent and oral PARP inhibitor
1445468
664993-53-7
JW 55, 99%
Description:
a potent and selective β-catenin signaling pathway inhibitor
a potent and selective β-catenin signaling pathway inhibitor
1833902
92831-11-3
MN-64, 98%
Description:
a potent tankyrase 1 inhibitor
a potent tankyrase 1 inhibitor
1413167
283173-50-2
Rucaparib, 98%
Description:
an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay,
an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay,
968129
344458-15-7
PJ34 Hydrochloride, 97%
Description:
an inhibitor of PARPl1/2 with IC50 of 110 nM and 86 nM, respectively.
an inhibitor of PARPl1/2 with IC50 of 110 nM and 86 nM, respectively.
161191
3544-24-9
3-Aminobenzamide, 98%
Description:
a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion
a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion
942871
763113-22-0
Olaparib, 99%
Description:
PARP inhibitor
PARP inhibitor
2286544
1609960-30-6
TH287, 97%
Description:
a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM
a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM
1866853
1609960-31-7
TH588, 99%
Description:
a first-in-class nudix hydrolase family inhibitor
a first-in-class nudix hydrolase family inhibitor
918053
103060-53-3
Daptomycin, 99%
Description:
a lipopeptide antibiotic
a lipopeptide antibiotic
1888727
1533426-72-0
SCR7, 99%
Description:
a DNA Ligase IV inhibitor with anticancer activity
a DNA Ligase IV inhibitor with anticancer activity
150210
18942-26-2
Chebulinic acid, 98%
Description:
a potent natural inhibitor of M. tuberculosis DNA gyrase
a potent natural inhibitor of M. tuberculosis DNA gyrase
242090
73-24-5
Adenine, 100%
Description:
a purine derivative and a nucleobase with a variety of roles in biochemistry
a purine derivative and a nucleobase with a variety of roles in biochemistry
258050
4291-63-8
2-Chloro-2'-deoxyadenosine, 99%
Description:
an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis
an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis
271269
122111-03-9
Gemcitabine hydrochloride, 99%
Description:
a DNA synthesis inhibitor with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM in BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells, respectively.
a DNA synthesis inhibitor with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM in BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells, respectively.
274238
443-48-1
Metronidazole, 99%
Description:
a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa
a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa
293018
127-07-1
Hydroxyurea, 98%
Description:
a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase
a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase
349577
10212-25-6
Cyclocytidine hydrochloride, 98%
Description:
an important antileukemia drugs
an important antileukemia drugs
366272
147-94-4
Cytosine β-D-arabinofuranoside, 99%
Description:
an antimetabolic agent and DNA synthesis inhibitor
an antimetabolic agent and DNA synthesis inhibitor
382010
321-30-2
Adenine sulfate, 99%
Description:
a purine derivative
a purine derivative
391047
73-24-5
Adenine, 99%
Description:
a purine derivative and a nucleobase with a variety of roles in biochemistry
a purine derivative and a nucleobase with a variety of roles in biochemistry
392078
154361-50-9
Capecitabine, 99%
Description:
an oral prodrug that is converted to its active metabolite, 5-FU, by thymidine phosphorylase
an oral prodrug that is converted to its active metabolite, 5-FU, by thymidine phosphorylase
399796
58-96-8
Uridine, 99%
Description:
a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond
a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond
405632
2922-28-3
Adenine hydrochloride, 98%
Description:
a purine derivative with a variety of roles in biochemistry
a purine derivative with a variety of roles in biochemistry
588536
13292-46-1
Rifampicin, 98%
Description:
a potent and broad spectrum antibiotic against bacterial pathogens
a potent and broad spectrum antibiotic against bacterial pathogens
792435
103060-53-3
Daptomycin, 95%
Description:
a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms
a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms
904475
75507-68-5
Flupirtine maleate salt, 97%
Description:
a selective neuronal potassium channel opener, NMDA receptor antagonist
a selective neuronal potassium channel opener, NMDA receptor antagonist
1563982
309271-94-1
Inauhzin, 98%
Description:
a dual SirT1/IMPDH2 inhibitor
a dual SirT1/IMPDH2 inhibitor
125841
98-92-0
Nicotinamide, 98%
Description:
an inhibitor of SIRT1
an inhibitor of SIRT1
259196
501-36-0
Resveratrol, 98%
Description:
a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties
a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties
984758
119413-54-6
Topotecan Hydrochloride, 98%
Description:
a Topoisomerase I inhibitor with potent antineoplastic activities
a Topoisomerase I inhibitor with potent antineoplastic activities
217292
186826-86-8
Moxifloxacin Hydrochloride, 98%
Description:
a synthetic fluoroquinolone antibiotic agent
a synthetic fluoroquinolone antibiotic agent
130846
97682-44-5
Irinotecan, 99%
Description:
a water soluble topoisomerase I inhibitor
a water soluble topoisomerase I inhibitor
460858
519-23-3
Ellipticine, 98%
Description:
a potent antineoplastic agent; inhibits DNA topoisomerase II activities
a potent antineoplastic agent; inhibits DNA topoisomerase II activities
2286646
522650-83-5
SW044248, 98%
Description:
a non-canonical topoisomerase I inhibitor
a non-canonical topoisomerase I inhibitor
113424
25316-40-9
Doxorubicin hydrochloride, 98%
Description:
an antibiotic agent
an antibiotic agent
114089
86639-52-3
SN-38, 99%
Description:
an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively
an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively
116557
23541-50-6
Daunorubicin hydrochloride, 97%
Description:
an inhibits both DNA and RNA synthesis
an inhibits both DNA and RNA synthesis
194237
56390-09-1
Epirubicin hydrochloride, 98%
Description:
a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase
a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase
289285
70476-82-3
Mitoxantrone hydrochloride, 99%
Description:
a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM
a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM
320523
33419-42-0
Etoposide, 98%
Description:
a chemotherapy medication used for the treatments of a number of types of cancer, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA
a chemotherapy medication used for the treatments of a number of types of cancer, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA
563738
29767-20-2
Teniposide, 98%
Description:
N/A
N/A
987783
136572-09-3
Irinotecan hydrochloride trihydrate, 98%
Description:
a water soluble topoisomerase I inhibitor with antitumor activity
a water soluble topoisomerase I inhibitor with antitumor activity
921481
85622-93-1
Temozolomide, 99%
Description:
an oral DNA alkylating agent used to treat some brain cancers,Solubility:≥20.83 mg/mL (DMSO)
an oral DNA alkylating agent used to treat some brain cancers,Solubility:≥20.83 mg/mL (DMSO)
964150
52-24-4
Thio-TEPA, 98%
Description:
a DNA alkylating agent, with antitumor activity
a DNA alkylating agent, with antitumor activity
251696
61825-94-3
Oxaliplatin, 95%
Description:
a DNA/RNA synthesis inhibitor
a DNA/RNA synthesis inhibitor
274584
41575-94-4
Carboplatin, 98%
Description:
a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death
a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death
275688
15663-27-1
cis-Diamineplatinum(II) dichloride, 99%
Description:
a DNA/RNA synthesis inhibitor
a DNA/RNA synthesis inhibitor
591713
3543-75-7
Bendamustine hydrochloride, 98%
Description:
a DNA-damaging agent
a DNA-damaging agent
608272
3778-73-2
Ifosfamide, 98%
Description:
an alkylating chemotherapeutic agent with activity against a wide range of tumors
an alkylating chemotherapeutic agent with activity against a wide range of tumors
996989
21679-14-1
Fludarabine, 98%
Description:
a DNA synthesis inhibitor
a DNA synthesis inhibitor
925039
121032-29-9
Nelarabine, 98%
Description:
a purine nucleoside analog and DNA synthesis inhibitor
a purine nucleoside analog and DNA synthesis inhibitor
150037
320-67-2
5-Azacytidine, 99%
Description:
a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases
a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases
180939
51-21-8
5-Fluorouracil, 99%
Description:
a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools
a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools
241600
50-91-9
2'-Deoxy-5-fluorouridine, 98%
Description:
an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1
an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1
255294
5536-17-4
Vidarabine, 98%
Description:
an antiviral drug which is active against herpes simplex and varicella zoster viruses
an antiviral drug which is active against herpes simplex and varicella zoster viruses
308447
4342-03-4
Dacarbazine, 98%
Description:
an antineoplastic agent
an antineoplastic agent
330390
123318-82-1
Clofarabine, 98%
Description:
a ribonucleotide reductase inhibitor
a ribonucleotide reductase inhibitor
339804
2353-33-5
5-Aza-2'-deoxycytidine, 99%
Description:
a potent inhibitor of DNA methyltransferase
a potent inhibitor of DNA methyltransferase
409544
6112-76-1
6-Mercaptopurine monohydrate, 99%
Description:
a DNA/RNA synthesis inhibitor
a DNA/RNA synthesis inhibitor
515848
17902-23-7
Tegafur, 98%
Description:
a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil
a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil
552943
70-00-8
Trifluorothymidine, 98%
Description:
an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis
an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis
579031
59-14-3
5-Bromo-2'-deoxyuridine, 99%
Description:
a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells
a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells
2275949
1233948-35-0
ELR510444, 98%
Description:
a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation
a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation
618172
168555-66-6
Fosbretabulin disodium, 98%
Description:
a microtubule destabilizing drug, a type of vascular-targeting agent,Solubility:≥4.5 mg/mL (H2O)
a microtubule destabilizing drug, a type of vascular-targeting agent,Solubility:≥4.5 mg/mL (H2O)
890634
219989-84-1
Ixabepilone, 98%
Description:
an orally bioavailable microtubule inhibitor
an orally bioavailable microtubule inhibitor
998523
19542-67-7
BAY 11-7082, 99%
Description:
a NF-κB inhibitor
a NF-κB inhibitor
952639
1572414-83-5
ML-323, 99%
Description:
a reversible, potent USP1-UAF1 inhibitor
a reversible, potent USP1-UAF1 inhibitor
914942
882257-11-6
P005091, 99%
Description:
a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7)
a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7)
977952
856243-80-6
WP1130, 99%
Description:
a cell-permeable deubiquitinase (DUB) inhibitor
a cell-permeable deubiquitinase (DUB) inhibitor
268355
154-42-7
2-Amino-6-purinethiol, 98%
Description:
an anti-leukemia and immunosuppressant agent
an anti-leukemia and immunosuppressant agent
913396
301836-43-1
D4476, 99%
Description:
a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1)
a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1)
624971
186611-52-9
IC261, 99%
Description:
a selective, ATP-competitive CK1 inhibitor
a selective, ATP-competitive CK1 inhibitor
1734614
639052-78-1
LH846, 98%
Description:
a selective inhibitor of CKIδ
a selective inhibitor of CKIδ
1433443
950912-80-8
PF-670462, 98%
Description:
a potent and selective inhibitor of casein kinase (CK1ε and CK1δ)
a potent and selective inhibitor of casein kinase (CK1ε and CK1δ)
1239125
1009820-21-6
Silmitasertib, 98%
Description:
a potent and selective ATP-competitive CK2 inhibitor
a potent and selective ATP-competitive CK2 inhibitor
935721
150399-23-8
Pemetrexed disodium, 99%
Description:
a novel antifolate
a novel antifolate
1564220
307543-71-1
STF-083010, 98%
Description:
an Ire1 inhibitor
an Ire1 inhibitor
994764
1418013-75-8
NMS-873, 98%
Description:
a potent, selective allosteric VCP/p97 inhibitor
a potent, selective allosteric VCP/p97 inhibitor
1578772
1337531-36-8
GSK2606414, 99%
Description:
a cell-permeable and orally available PERK inhibitor
a cell-permeable and orally available PERK inhibitor
